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首页> 外文期刊>Current Biology: CB >Spike Timing Matters in Novel Neuronal Code Involved in Vibrotactile Frequency Perception
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Spike Timing Matters in Novel Neuronal Code Involved in Vibrotactile Frequency Perception

机译：诸如vibrotactive频率感知的新型神经元代码中的尖峰定时问题

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Skin vibrations sensed by tactile receptors contribute significantly to the perception of object properties during tactile exploration [1-4] and to sensorimotor control during object manipulation [5]. Sustained low-frequency skin vibration ( 60 Hz) evokes a distinct tactile sensation referred to as flutter whose frequency can be clearly perceived [6]. How afferent spiking activity translates into the perception of frequency is still unknown. Measures based on mean spike rates of neurons in the primary somatosensory cortex are sufficient to explain performance in some frequency discrimination tasks [7-11]; however, there is emerging evidence that stimuli can be distinguished based also on temporal features of neural activity [12, 13]. Our study's advance is to demonstrate that temporal features are fundamental for vibrotactile frequency perception. Pulsatile mechanical stimuli were used to elicit specified temporal spike train patterns in tactile afferents, and subsequently psychophysical methods were employed to characterize human frequency perception. Remarkably, the most salient temporal feature determining vibrotactile frequency was not the underlying periodicity but, rather, the duration of the silent gap between successive bursts of neural activity. This burst gap code for frequency represents a previously unknown form of neural coding in the tactile sensory system, which parallels auditory pitch perception mechanisms based on purely temporal information where longer inter-pulse intervals receive higher perceptual weights than short intervals [14]. Our study also demonstrates that human perception of stimuli can be determined exclusively by temporal features of spike trains independent of the mean spike rate and without contribution from population response factors.
机译：由触觉受体感测的皮肤振动在触觉勘探[1-4]期间对物体特性的感知有显着贡献[1-4]和物体操纵期间的传感器控制[5]。持续的低频皮肤振动（＆ 60 Hz）引起了称为颤动的明显触觉感觉，其频率可以清楚地感知[6]。传入的尖刺活动如何转化为对频率的看法仍然未知。基于初级躯体病皮层中的均线的平均尖峰率的措施足以在一些频率歧视任务中解释性能[7-11];然而，出现了新兴的证据，即可以基于神经活动的时间特征来区分刺激[12,13]。我们的研究进展是证明时间特征是振动触发频率感知的基础。脉动机械刺激用于引出触觉交流中的指定时间尖峰列车模式，随后使用心理物理方法表征人频率感知。值得注意的是，确定振动率频率的最突出的时间特征不是底层周期性，而是，而是，相反，在连续突发之间的神经活动突发之间的静音间隙的持续时间。该突发的频率频率代表触觉感觉系统中的先前未知的神经编码形式，其基于纯粹的时间信息使听觉音高感知机制相似，其中较长的脉冲间隔接收比短间隔更高的感知权重[14]。我们的研究还表明，人类对刺激的感知，可以通过独立于平均尖峰率的尖峰列车的时间特征来专门确定，并且没有人口响应因素的贡献。

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