An Adenosine Receptor for Olfaction in Fish

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An Adenosine Receptor for Olfaction in Fish

机译：用于鱼类嗅觉的腺苷受体

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Nucleotides released from food sources into environmental water are supposed to act as feeding cues for many fish species. However, it remains unknown how fish can sensitively detect those nucleotides. Here we discover a novel olfactory mechanism for ATP sensing in zebrafish. Upon entering into the nostril, ATP is efficiently converted into adenosine through enzymatic reactions of two ecto-nucleotidases expressed in the olfactory epithelium. Adenosine subsequently activates a small population of olfactory sensory neurons expressing a novel adenosine receptor A2c that is unique to fishes and amphibians. The information is then transmitted to a single glomerulus in the olfactory bulb and further to four regions in higher olfactory centers. These results provide conclusive evidence for a sophisticated enzyme-linked receptor mechanism underlying detection of ATP as a food-derived attractive odorant linking to foraging behavior that is crucial and common to aquatic lower vertebrates.

机译：从食物来源释放到环境用水中的核苷酸应该作为许多鱼类的喂养线索。然而，它仍然是如何敏感性地检测这些核苷酸的未知。在这里，我们发现斑马鱼的ATP感应的新型嗅觉机制。进入鼻孔后，ATP通过在嗅觉上皮中表达的两种核苷酸酶的酶促反应有效地转化为腺苷。腺苷随后激活表达新的腺苷受体A2C的小嗅觉感觉神经元，这是鱼类和两栖动物的独特。然后将信息传递到嗅球中的单个肾小球，并进一步到更高嗅觉中心的四个区域。这些结果提供了一种确凿的证据证明了依赖于ATP的复杂酶联受体机制作为食物衍生的含有吸气性的气味，与用于觅食行为至关重要的，与水生低脊椎动物至关重要。

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《Current Biology: CB》 |2017年第10期|共15页
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中图分类生物科学;
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1. An Adenosine Receptor for Olfaction in Fish [J] . Wakisaka Noriko, Miyasaka Nobuhiko, Koide Tetsuya, Current Biology: CB . 2017,第10期

机译：用于鱼类嗅觉的腺苷受体
2. Distribution and expression of A1 adenosine receptors, adenosine deaminase and adenosine deaminase-binding protein (CD26) in goldfish brain. [J] . Beraudi A, Traversa U, Villani L, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2003,第6期

机译：金鱼脑中A1腺苷受体，腺苷脱氨酶和腺苷脱氨酶结合蛋白（CD26）的分布和表达。
3. Targeting expression of adenosine receptors during hypoxia induced angiogenesis - A study using zebrafish model [J] . Panneerselvan Navina, Ragunathan Malathi Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

机译：缺氧诱导血管生成期间腺苷受体的表达 - 一种使用斑马鱼模型的研究
4. Quantitative FRET measurement of the interaction of A_1 adenosine receptors and A_(2A) adenosine receptors in living cell [C] . Yating Lin, Yimei Huang, Zhiwei Wu, Optics in health care and biomedical optics VIII . 2018

机译：活细胞中A_1腺苷受体和A_（2A）腺苷受体相互作用的定量FRET测量
5. The Modulatory Role of Caffeine and Other Adenosine Receptor Antagonists onto Spinal Locomotor Circuits: Evidence for its Dependence on Adenosine A1- Dopamine D1 Receptor Heteromers in Spinal Motoneurons. [D] . Rivera-Oliver, Marla. 2017

机译：咖啡因和其他腺苷受体拮抗剂对脊髓运动回路的调节作用：证据表明其依赖于脊髓Motonuron中的腺苷A1-多巴胺D1受体异源异构体。
6. Identification of Zebrafish A2 Adenosine Receptors and Expression in Developing Embryos [O] . Wendy Boehmler, Jessica Petko, Matthew Woll, -1

机译：斑马鱼A2腺苷受体的鉴定及其在胚胎发育中的表达
7. Identification of zebrafish A2 adenosine receptors and expression in developing embryos [O] . Wendy Boehmler, Jessica Petko, Matthew Woll, 2009

机译：斑马鱼A2腺苷受体的鉴定和发展中胚胎的表达

An Adenosine Receptor for Olfaction in Fish

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