Preparation of Pyrazinamide Eutectics versus Cocrystals Based on Supramolecular Synthon Variations

Rajbongshi Trishna; Sarmah Kashyap Kumar; Sarkar Ankita; Ganduri Ramesh; Cherukuyada Suryanarayan; Thakur Tejender S.; Thakuria Ranjit

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Preparation of Pyrazinamide Eutectics versus Cocrystals Based on Supramolecular Synthon Variations

机译：基于超分子综合变化的吡嗪酰胺酰胺的制备与Cocrystals

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Cocrystallization of the antituberculosis drug pyrazinamide (PZA) with several substituted aromatic carboxylic acids as coformers was studied. The combinations were analyzed by X-ray diffraction and melting behavior to assess the formation of eutectic versus cocrystal. Benzoic acid, cinnamic acid, and N-heterocycle coformers gave eutectics, whereas the majority of their hydroxyl/methoxy substitutes formed cocrystals with PZA. X-ray crystal structures were obtained for some cocrystals, and binary phase diagrams were constructed to determine eutectic compositions. Differences in functional group position and variations in supramolecular growth were found to dictate the formation of eutectics versus cocrystals. Supramolecular synthon energy calculations on selected combinations validated the formation of eutectic versus cocrystal.

机译：研究了用几种取代的芳族羧酸作为CoFormers的抗尿嘧啶吡嗪酰胺（PZA）的抗组合。通过X射线衍射和熔化行为分析组合，以评估共晶与CoCrystal的形成。苯甲酸，肉桂酸和N-杂环Coformers赋予了激光，而它们的大部分羟基/甲氧基替代物用PZA形成钴。获得X射线晶体结构，用于一些酰基，构建二元相图以确定共晶组合物。发现官能团定位的差异和超分子生长的变化决定了对共晶与钴的形成。对所选组合的超分子合成能量计算验证了共晶与CoCrystal的形成。

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来源
《Crystal growth & design》 |2018年第11期|共12页
作者
Rajbongshi Trishna; Sarmah Kashyap Kumar; Sarkar Ankita; Ganduri Ramesh; Cherukuyada Suryanarayan; Thakur Tejender S.; Thakuria Ranjit;
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作者单位

Gauhati Univ Dept Chem Gauhati 781014 Assam India;

Gauhati Univ Dept Chem Gauhati 781014 Assam India;

Gauhati Univ Dept Chem Gauhati 781014 Assam India;

Indian Inst Sci Solid State &

Struct Chem Unit Bengaluru 560012 Karnataka India;

Indian Inst Sci Solid State &

Struct Chem Unit Bengaluru 560012 Karnataka India;

CSIR Cent Drug Res Inst Mol &

Struct Biol Div Lucknow 226031 Uttar Pradesh India;

Gauhati Univ Dept Chem Gauhati 781014 Assam India;

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正文语种 eng
中图分类晶体学;
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1. Preparation of Pyrazinamide Eutectics versus Cocrystals Based on Supramolecular Synthon Variations [J] . Rajbongshi Trishna, Sarmah Kashyap Kumar, Sarkar Ankita, Crystal growth & design . 2018,第11期

机译：基于超分子综合变化的吡嗪酰胺酰胺的制备与Cocrystals
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3. Self-assembly of cardanol based supramolecular synthons to photoresponsive nanospheres: light induced size variation at the nanoscale [J] . Mahesh Sankarapillai, Raju Dawn, Arathi A. S., RSC Advances . 2014,第80期

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4. Terahertz Investigation of Drug-Drug Cocrystal Involving 4-aminosalicylic Acid and Pyrazinamide [C] . Ziming Zhang, Yong Du, Zhi Hong International Conference on Infrared, Millimeter, and Terahertz Waves . 2020

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5. Development of Sulfur and Selenium Halogen Bonded Synthons and Mechanosynthesis of Halogen Bonded Cocrystals [D] . Siegfried, Adam Michael. 2016

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7. Preparation of Pyrazinamide Eutectics versus Cocrystals Based on Supramolecular Synthon Variations [O] . -1

机译：基于超分子综合变化的吡嗪酰胺共晶与酰基的制备

Preparation of Pyrazinamide Eutectics versus Cocrystals Based on Supramolecular Synthon Variations

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