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Pseudopolymorph Control of L-Phenylalanine Achieved by Laser Trapping

机译：激光诱捕实现L-苯丙氨酸的假青少药物

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摘要

We demonstrate pseudopolymorph control of L-phenylalanine (L-Phe) with laser trapping method by tuning laser power, polarization, and initial solution concentration. When a continuous-wave near-infrared laser beam of 1064 nm was focused at an air/solution interface of L-Phe D2O solutions with different saturation, L-Phe crystallization was always observed within 30 min-irradiation, even from unsaturated solution. Either whisker- or plate-like crystals were generated depending on given conditions, and identified by Raman spectroscopy to be two L-Phe pseudopolymorphs of monohydrate and anhydrous forms, respectively. The absolute control of L-Phe pseudopolymorphism was achieved by changing the initial solution concentration. In unsaturated solution, laser trapping always produced only one anhydrous crystal at the focus, which can never be produced on spontaneous nucleation at ordinary temperatures and pressures, while in supersaturated solution, a number of monohydrate crystals were densely distributed in an area ranging from 500 mu m to 1 mm away from the focus. Moreover, in saturated solution, laser power and polarization contributed to the pseudopolymorphism. As laser power was increased, linearly and circularly polarized laser irradiation increased the formation probability of the anhydrous and monohydrate crystals, respectively. The dynamics and mechanism of laser trapping-induced pseudopolymorphism of L-Phe are discussed in view of the formation of a highly concentrated domain consisting of the liquid-like clusters and the stability of the clusters in the domain under electromagnetic field of trapping laser.
机译：通过调节激光功率，极化和初始溶液浓度，通过激光捕获方法证明L-苯丙氨酸（L-PHE）的假聚物对照。当在具有不同饱和的L-PHE D2O溶液的空气/溶液界面处聚焦1064nm的连续波近红外激光束时，即使来自不饱和溶液，始终在30分钟照射中始终观察到L-PHE结晶。根据给定条件产生晶须或板状晶体，并通过拉曼光谱法鉴定为两水合物和无水形式的两种L-Phe pseudolymorph。通过改变初始溶液浓度来实现L-PHE假聚合物的绝对控制。在不饱和溶液中，激光捕获总是在焦点上仅生产一种无水晶体，这不能在普通温度和压力下在自发成核上产生，而在过饱和溶液中，在500μm的区域中致密地分布了许多一水合物晶体距离焦点1毫米至1毫米。此外，在饱和溶液中，激光功率和极化有助于伪多聚合物。随着激光功率增加，线性和圆偏振的激光照射分别增加了无水和一水合物晶体的形成概率。考虑到形成由液体样簇和诱捕激光器的电磁场下的域中的簇的高浓度域和簇的稳定性的形成，讨论了L-PHE激光诱导的L-PHE的动力学和机制。

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