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首页> 外文期刊>Crystal growth & design >Lysine as Size-Control Additive in a Bioinspired Synthesis of Pure Superparamagnetic Magnetite Nanoparticles
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Lysine as Size-Control Additive in a Bioinspired Synthesis of Pure Superparamagnetic Magnetite Nanoparticles

机译：赖氨酸作为纯超顺磁磁铁矿纳米粒子的生物透明合成中的赖氨酸尺寸控制添加剂

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Magnetite nanoparticles (MNPs) are being used in a number of nanotechnological applications, especially biomedical, both in diagnosis and in therapeutics such as hyperthermia agents and as drug nanocarriers for targeted chemotherapy. However, the development of efficient methodologies to produce novel MNPs with the specific requirements needed for biomedical applications is still challenging. In this context, biomimetic approaches taking use of magnetosome proteins expressed as recombinant and/or polyamino acids are becoming of great interest. In fact, these protocols give rise to magnetite nanoparticles of adequate size, magnetic properties and surface functionalization that make them compatible for biomedical applications. In this respect, herein we show for the first time that lysine (Lys), unlike other amino acids like arginine (Arg), is able to exert a control over the size of MNPs produced in water and at room temperature. This control occurs through the stabilization of the magnetite nuclei by the lateral ammonium group of Lys. The strength of such stabilization allows a further release of these previously bonded nuclei to allow the further growth of the larger ones, thus resulting in larger crystals compared to those obtained by using Arg or no amino acids at all. MNPs obtained by the mediation of this amino acid are fairly large (30 nm) while being superparamagnetic at room temperature. They present an isoelectric point of 4, which may allow the coupling/release of these MNPs to other molecules based on electrostatic interaction, a large magnetic moment per particle and high magnetization saturation. This study highlights the effects that biological additives have in the process of magnetite biomineralization and goes along the line of previous reports using magnetosome proteins and polyamino acids.
机译：磁铁矿纳米颗粒（MNP）用于许多纳米技术应用，特别是生物医学，诊断和治疗剂，如热疗剂和靶向化疗的药物纳米载体。然而，开发有效的方法，以生产具有生物医学应用所需的特定要求的新型MNP仍然具有挑战性。在这种情况下，采用用作重组和/或聚氨基酸表达的磁体蛋白的仿生方法变得非常兴趣。事实上，这些方案产生了足够大小，磁性和表面官能化的磁铁矿纳米颗粒，使其使其兼容生物医学应用。在这方面，在本文中，我们显示出赖氨酸（Lys）不同于其他氨基酸（如精氨酸）（Arg），能够在水中和室温下产生的尺寸上的控制。这种控制通过侧向铵的液体稳定磁性核来稳定。这种稳定化的强度允许进一步释放这些先前粘合的核，以允许较大的较大的核的进一步生长，从而与通过使用Arg或NO NO氨基酸获得的那些相比较大的晶体。通过该氨基酸的调解获得的MNP相当大（30nm），同时在室温下超顺磁性。它们呈现4的等电点，其可以允许基于静电相互作用，每个粒子的大磁矩和高磁化饱和度耦合/释放这些MNP到其他分子。本研究突出了生物添加剂在磁铁矿生物矿化过程中具有的效果，并且使用磁体蛋白和聚氨基酸的先前报道线。

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