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Controlling the Size and Polymorphism of Calcium Carbonate Hybrid Particles Using Natural Biopolymers

机译：使用天然生物聚合物控制碳酸钙杂交颗粒的尺寸和多态性

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Calcium carbonate (CaCO3) nanoparticles have diverse applications in biomedicine, including ultrasound imaging, biosensing, drug delivery, and theranostics. One of its crystal polymorphs, vaterite, exhibits many unique features, such as its high solubility, porosity, and spherical shape, which make it suitable for drug delivery; however, the instability of this polymorph makes the large-scale fabrication of these particles challenging. In this work, we utilized a fast precipitation technique to fabricate CaCO3 hybrid particles, with the biocompatible polymeric additives bovine serum albumin (BSA) and polydopamine (PDA), a polymer with unique optical properties. The results showed that BSA and PDA can be used together to produce hybrid particles with variable sizes and polymorph compositions, depending on the reaction or mixing time applied. We also demonstrated that, by controlling other fabrication process parameters, including the PDA polymerization time, addition order of the salts, and the pairing of the salts with the polymer additives, we could tune the physicochemical properties of the resulting CaCO3 hybrid particles. These findings are important in designing hybrid particle systems with tailored properties for specific applications, including contrast-enhanced ultrasound and photoacoustic imaging, drug delivery, photothermal therapy, and cancer theranostics.
机译：碳酸钙（CaCO 3）纳米颗粒在生物医学中具有不同的应用，包括超声成像，生物溶剂，药物递送和治疗剂。其一种晶体多晶型物，Vaterite展现出许多独特的特征，例如其高溶解度，孔隙率和球形，使其适用于药物递送;然而，这种多晶型物的不稳定性使得这些颗粒的大规模制造具有挑战性。在这项工作中，我们利用了一种快速沉淀技术来制造CaCO3杂交颗粒，用生物相容性聚合物添加剂牛血清白蛋白（BSA）和聚德多样（PDA），具有独特的光学性质的聚合物。结果表明，BSA和PDA可以一起使用，以产生具有可变尺寸和多晶型组合物的杂化颗粒，这取决于施加的反应或混合时间。我们还证明，通过控制其他制造工艺参数，包括PDA聚合时间，盐的添加顺序，以及与聚合物添加剂的盐的配对，我们可以调整所得CaCO3杂交颗粒的物理化学性质。这些发现在设计具有针对特定应用的定制性质的混合颗粒系统方面很重要，包括对比增强的超声和光声成像，药物递送，光热疗和癌症治疗。

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