...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Crystal growth & design >Novel Pharmaceutical Cocrystals and Salts of Bumetanide
【24h】

Novel Pharmaceutical Cocrystals and Salts of Bumetanide

机译：新型药物酰胺和硼酸盐的盐

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

New crystalline forms of bumetanide, namely, four cocrystals, two salts, and one salt-cocrystal were crystallized. Urea and lactams such as valerolactam, caprolactam, and N-methyl caprolactam formed cocrystals with bumetanide, whereas 4-aminopyridine gave a salt. Piperazine afforded a salt hydrate, and 5-fluorocytosine gave a salt-cocrystal. The supramolecular synthons in bumetanide-lactam cocrystals are an amide dimer between drug and coformer, and acid homo dimer between bumetanide molecules. In bumetanide salts, the acid proton is transferred from bumetanide to coformer amine, whereas in bumetanide salt-cocrystal proton transfer and free acid were observed in the crystal structure. Similarly, the cytosine salt-cocrystal of bumetanide and fluorocytosine also gave a salt-cocrystal adduct. The acid proton of bumetanide is transferred to the 2-amino pyridine base of cytosine as a salt, and on the other side of the drug molecule the sulfonamide interacts with the syn amide part of cytosine. Furthermore, solubility, dissolution, and diffusion membrane permeability experiments were performed on all new solid forms. The piperazine salt shows high dissolution and permeability crossover when compared to other binary forms of bumetanide.
机译：新结晶形式的硼乙胺，即四个酰基晶体，两个盐和一个盐 - 烯库结晶。尿氨酰胺，己内酰胺和N-甲基己内酰胺等尿素和内酰胺与硼丙烯，而4-氨基吡啶得到盐。哌嗪提供盐水合物，5-氟核苷酸得到盐 - 烯晶。硼酸内酯 - 内酰胺酰胺的超分子合成胶剂是药物和共甲烷之间的酰胺二聚体，硼酸酐分子之间的酸均二聚体。在硼酸盐盐中，酸质子从硼乙炔转移到CoFormer胺，而在硼丙烯酸盐盐 - 晶体化质子转移和在晶体结构中观察到游离酸。类似地，硼酸铋和氟核苷酸的胞嘧啶盐 - 酸盐也得到了盐 - 烯晶的加合物。将硼铀的酸性质子转移到胞苷的胞嘧啶的2-氨基吡啶基碱作为盐，并在药物分子的另一侧与磺酰胺相互作用，与胞嘧啶的SYN酰胺部分相互作用。此外，对所有新的固体形式进行溶解性，溶解和扩散膜渗透性实验。与其他二元形式的硼乙胺相比，哌嗪盐显示出高溶解和渗透性交叉。

著录项

  • 来源
    《Crystal growth & design》 |2020年第2期|共11页
  • 作者

    Allu Suryanarayana; Bolla Geetha; Tothadi Srinu; Nangia Ashwini K.;

  • 作者单位

    Univ Hyderabad Sch Chem Prof CR Rao Rd Cent Univ PO Hyderabad 500046 India;

    Univ Hyderabad Sch Chem Prof CR Rao Rd Cent Univ PO Hyderabad 500046 India;

    Natl Chem Lab CSIR Mat Chem Div Dr Homi Bhabha Rd Pune 411008 Maharashtra India;

    Univ Hyderabad Sch Chem Prof CR Rao Rd Cent Univ PO Hyderabad 500046 India;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号