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首页> 外文期刊>American Journal of Physiology >Effects of a high-sodium/low-potassium diet on renal calcium, magnesium, and phosphate handling
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Effects of a high-sodium/low-potassium diet on renal calcium, magnesium, and phosphate handling

机译：高钠/低钾饮食对肾钙，镁和磷酸盐处理的影响

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摘要

The distal convoluted tubule (DCT) of the kidney plays an important role in blood pressure regulation by modulating Na+ reabsorption via the Na+-Cl? cotransporter (NCC). A diet containing high salt (NaCl) and low K+ activates NCC, thereby causing Na+ retention and a rise in blood pressure. Since high blood pressure, hypertension, is associated with changes in serum calcium (Ca2+) and magnesium (Mg2+) levels, we hypothesized that dietary Na+ and K+ intake affects Ca2+ and Mg2+ transport in the DCT. Therefore, the present study aimed to investigate the effect of a high-Na+/low-K+ diet on renal Ca2+ and Mg2+ handling. Mice were divided in four groups and fed a normal-Na+/normal-K+, normal-Na+/low-K+, high-Na+/normal-K+, or high-Na+/low-K+ diet for 4 days. Serum and urine were collected for electrolyte and hormone analysis. Gene and protein expression of electrolyte transporters were assessed in kidney and intestine by qPCR and immunoblotting. Whereas Mg2+ homeostasis was not affected, the mice had elevated urinary Ca2+ and phosphate (Pi) excretion upon high Na+ intake, as well as significantly lower serum Ca2+ levels in the high-Na+/low-K+ group. Alterations in the gene and protein expression of players involved in Ca2+ and Pi transport indicate that reabsorption in the proximal tubular and TAL is affected, while inducing a compensatory response in the DCT. These effects may contribute to the negative health impact of a high-salt diet, including kidney stone formation, chronic kidney disease, and loss of bone mineral density.
机译：通过Na + -Cl调节Na +重吸收，肾脏的远端卷积小管（DCT）在血压调节中起重要作用？ COTRANSPORTER（NCC）。含有高盐（NaCl）和低k +的饮食活化NCC，从而导致Na +保持和血压升高。由于高血压高血压与血清钙（Ca2 +）和镁（Mg2 +）水平的变化有关，我们假设膳食Na +和K +摄入量影响DCT中的Ca2 +和Mg2 +运输。因此，本研究旨在探讨高Na + / Low-K +饮食对肾CA2 +和MG2 +处理的影响。小鼠分为四组，并喂养正常-Na + /正常-K +，正常-NA + /低k +，高Na + /普通-K +，或高Na + / Low-K +饮食4天。收集血清和尿液，用于电解质和激素分析。通过QPCR和免疫印迹，在肾脏和肠中评估电解质转运蛋白的基因和蛋白质表达。虽然Mg2 +稳态没有受到影响，但小鼠在高Na +摄入量上具有升高的尿Ca2 +和磷酸盐（pi）排泄，以及高Na + /低k +组中的血清Ca2 +水平显着降低。参与CA2 +和PI转运的球员基因和蛋白质表达的改变表明，近端管状和缩略的重吸收受影响，同时诱导DCT中的补偿响应。这些效果可能有助于高盐饮食的负面健康影响，包括肾结石形成，慢性肾病和骨密度损失。

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