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首页> 外文期刊>American Journal of Physiology >Toward better treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia?
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Toward better treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia?

机译：在与良性前列腺增生相关的更好的尿路症状更好的治疗方法？

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The most effective and fastest acting pharmacotherapeutic relievers of lower urinary Iract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) are the selective α_(1a)-adrenoceptor antagonists such as tamsulosin, silodosin, and alfuzosin (7). This class of drugs relieves symptoms primarily by inhibiting the binding of norepinephrine to α_(1a)-adrenoceptors located on the smooth muscle cells of the urethra and prostate. This antagonism of α_(1a)-adrenoceptors relaxes the urethral and prostatic smooth muscle allowing urine to flow more easily through the urethral obstruction caused by prostate enlargement. Despite this, the α_1-adrenoceptor antagonist class of drugs is only useful in treating mild to moderate symptoms associated with BPH. More severe symptoms require surgical intervention to widen the urelhral passage sufficiently to allow smoother flow of urine (8). Another important limitation of aiA-adrenoceptor antagonists is their efficacy, as improvement of urinary symptom scores and flow will generally not exceed 50%.
机译：与良性前列腺增生（BPH）相关的最有效和最快的药物治疗释放器（LUTS）是选择性α_（1A） - 肾上腺素受体拮抗剂，如Tamsulosin，Silodosin和Alfuzosin（7）。这类药物主要通过抑制位于尿道和前列腺的平滑肌细胞上的去甲肾上腺素至α_（1a） - 调节剂的结合来缓解症状。 α_（1A） - 一种拮抗剂的拮抗作用松弛尿道和前列腺平滑肌，使尿液更容易流动，通过前列腺增大引起的尿道梗阻。尽管如此，α_1-adrenoceptor拮抗剂类药物仅用于治疗与BPH相关的轻度至中度症状。更严重的症状需要手术干预以充分扩大尿道通道，以允许更平滑的尿液（8）。 AIA-adrenoceptor拮抗剂的另一个重要限制是它们的功效，随着泌尿症状评分和流量的改善通常不超过50％。

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