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首页> 外文期刊>American Journal of Physiology >Eight weeks of nitrate supplementation improves blood flow and reduces the exaggerated pressor response during forearm exercise in peripheral artery disease
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Eight weeks of nitrate supplementation improves blood flow and reduces the exaggerated pressor response during forearm exercise in peripheral artery disease

机译：八周的硝酸盐补充剂改善了血液流动，并在外周动脉疾病中进行前臂运动期间夸张的压力响应

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Peripheral artery disease (PAD) is characterized by a reduced blood flow (BF) and an elevated blood pressure (pressor) response during lower extremity exercise. Although PAD is evident in the upper extremities, no studies have determined BF and pressor responses during upper extremity exercise in PAD. Emerging evidence suggests that inorganic nitrate supplementation may serve as an alternative dietary strategy to boost nitric oxide bioavailability, improving exercising BF and pressor responses during exercise. The present study investigated 1) BF and pressor responses to forearm exercise in patients with PAD (n = 21) relative to healthy age-matched control subjects (n = 16) and 2) whether 8 wk of NaNO_3 supplementation influenced BF and pressor responses to forearm exercise in patients with PAD. Patients with moderate to severe PAD were randomly assigned to a NaNO_3 (1 g/day, n = 13)-treated group or a placebo (microcrystalline cellulose, n = 8)-treated group. Brachial artery forearm BF (FBF; via Doppler) and blood pressure (via finger pleth-ysmography) were measured during mild-intensity (~3.5-kg) and moderate-intensity (~7-kg) handgrip exercise. The absolute change (from baseline) in FBF was reduced (except in the 3.5-kg condition) and BP responses were increased in patients with PAD compared with healthy control subjects in 3.5- and 7-kg conditions (all P < 0.05). Plasma nitrate and nitrite were elevated, exercising (7-kg) AFBF was improved (from 141 ± 17 to 172 ± 20 ml/min), and mean arterial pressure response was reduced (from 13 ± 1 to 9 ± 1 mmHg, P < 0.05) in patients with PAD that received NaNO_3 supplementation for 8 wk relative to those that received placebo. These results suggest that the BF limitation and exaggerated pressor response to moderate-intensity forearm exercise in patients with PAD are improved with 8 wk of NaNO_3 supplementation.
机译：外周动脉疾病（垫）的特征在于降低血流（BF）和下肢运动期间升高的血压（压力）响应。虽然垫在上肢明显明显，但在垫中上肢运动期间没有研究确定的BF和压力响应。新兴的证据表明，无机硝酸盐补充剂可以作为促进一氧化氮生物利用度的替代膳食策略，在运动期间改善锻炼BF和压力反应。本研究研究了1）BF和压力响应对垫（n = 21）患者的前臂运动相对于健康年龄匹配的对照受试者（n = 16）和2）是否8周的纳米_3补充影响BF和压力响应前臂锻炼垫患者。中度至重度垫的患者被随机分配给纳米_3（1g / di，n = 13） - 处理基团或安慰剂（微晶纤维素，n = 8） - 治疗基团。在轻度强度（3.5kg）和中等强度（〜7-kg）手柄运动期间测量肱动脉前臂BF（FBF;通过多普勒）和血压（通过手指PLETH-YSMOCHOCE）。 FBF中的绝对变化（来自基线）（除3.5千克病症外），垫患者的BP反应增加，与3.5-和7-kg条件下的健康对照受试者（所有P <0.05）。血浆硝酸盐和亚硝酸盐升高，锻炼（7-kg）AFBF（从141±17±172±20×20ml / min），并且平均动脉压反应降低（从13±1至9±1 mmHg，P < 0.05）在垫的患者中，接受纳米_3相对于接受安慰剂的那些补充8周的补充。这些结果表明，用8周的纳米补充，改善了BF限制和夸大的压力对中等强度前臂锻炼的反应。

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