Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma

Arimoto Satomi; Hasegawa Takumi; Takeda Daisuke; Saito Izumi; Amano Rika; Akashi Masaya; Komori Takahide

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Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma

机译：口腔鳞状细胞癌中的淋巴管生成和淋巴结转移

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Background/Aim: Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. Patients and Methods: Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. Results: The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p0.01) and histological grade (p0.01 for podoplanin, p0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p0.01 for podoplanin, p0.05 for LYVE-1). Conclusion: Podoplanin and LYVE-1 were strongly associated with LN metastasis.

机译：背景/目的：肿瘤淋巴管发生在口腔鳞状细胞癌（OSCC）中的淋巴结（LN）转移中起着关键作用。本研究的目的是探讨泛蛋白和淋巴管内皮透明质酸受体1（Lyve-1）及其与核心转移和其他临床病理变量的关系。患者及方法：通过33例OSCC的样品中的定量实时PCR测定和免疫组化，研究了泊普坦和常规组织的表达和正常组织的表达。结果：两种基因的mRNA高表达水平具有统计学上显着较高的LN转移速率（P <0.01）和组织学级（P <0.01，P＆ Lyve-1的P <0.05）。每种基因的高表达，如免疫组织化学所示，具有统计学上显着的LN转移率（P

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来源
《Anticancer Research: International Journal of Cancer Research and Treatment》 |2018年第11期|共6页
作者
Arimoto Satomi; Hasegawa Takumi; Takeda Daisuke; Saito Izumi; Amano Rika; Akashi Masaya; Komori Takahide;
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作者单位

Kobe Univ Dept Oral &

Maxillofacial Surg Grad Sch Med Kobe Hyogo Japan;

Kobe Univ Dept Oral &

Maxillofacial Surg Grad Sch Med Kobe Hyogo Japan;

Kobe Univ Dept Oral &

Maxillofacial Surg Grad Sch Med Kobe Hyogo Japan;

Kobe Univ Dept Oral &

Maxillofacial Surg Grad Sch Med Kobe Hyogo Japan;

Kobe Univ Dept Oral &

Maxillofacial Surg Grad Sch Med Kobe Hyogo Japan;

Kobe Univ Dept Oral &

Maxillofacial Surg Grad Sch Med Kobe Hyogo Japan;

Kobe Univ Dept Oral &

Maxillofacial Surg Grad Sch Med Kobe Hyogo Japan;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Oral squamous cell carcinoma; lymphangiogenesis; lymph node metastasis; quantitative real-time PCR; immunohistochemistry;

机译：口腔鳞状细胞癌;淋巴管生成;淋巴结转移;定量实时PCR;免疫组化;

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专利

1. Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma [J] . Morita Yoshihiro, Hata Kenji, Nakanishi Masako, Clinical and experimental metastasis . 2015,第7期

机译：细胞纤连蛋白1促进人口腔鳞状细胞癌相关的VEGF-C表达，淋巴管生成和淋巴结转移
2. Lymphangiogenesis in Oral Squamous Cell Carcinoma: Correlation with VEGF-C Expression and Lymph Node Metastasis [J] . Manar A. Abdul-Aziz, Amina K. Amin, Dalia H. El-Rouby, International Journal of Dentistry . 2017,第Pta2期

机译：口腔鳞状细胞癌中的淋巴管发生：与VEGF-C表达和淋巴结转移相关
3. Lymphangiogenesis in Oral Squamous Cell Carcinoma: Correlation with VEGF-C Expression and Lymph Node Metastasis [J] . Manar A. Abdul-Aziz, Amina K. Amin, Dalia H. El-Rouby, International Journal of Dentistry . 2017,第Pta1期

机译：口腔鳞状细胞癌中的淋巴管发生：与VEGF-C表达和淋巴结转移相关
4. Central Lymph Node Metastasis as a Predictor for Lateral Lymph Node Metastasis in Clinically Node-Negative T3 and T4 Papillary Thyroid Carcinoma [C] . Zhe Han, Shuai Xue, Peisong Wang, International Conference on Information Technology in Medicine and Education . 2018

机译：中央淋巴结转移作为临床节点阴性T3和T4乳头状甲状腺癌中侧淋巴结转移的预测因子
5. Gene expression and immune cell profiles in oral squamous cell carcinoma: Insights into lymphatic metastasis. [D] . O'Donnell, Rebekah K. 2006

机译：口腔鳞状细胞癌中的基因表达和免疫细胞谱：对淋巴转移的见解。
6. Lymphangiogenesis in Oral Squamous Cell Carcinoma: Correlation with VEGF-C Expression and Lymph Node Metastasis [O] . Manar A. Abdul-Aziz, Amina K. Amin, Dalia H. El-Rouby, 2017

机译：口腔鳞状细胞癌的淋巴管生成：与VEGF-C表达和淋巴结转移的关系。
7. Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma [O] . SATOMI ARIMOTO, TAKUMI HASEGAWA, DAISUKE TAKEDA, 2018

机译：口腔鳞状细胞癌中的淋巴管生成和淋巴结转移

Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma

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