Micro-capillary-based self-referencing surface plasmon resonance biosensor for determination of transferrin

Chen Shimeng; Liu Yun; Liu Zigeng; Chu Shuwen; Peng Wei

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Micro-capillary-based self-referencing surface plasmon resonance biosensor for determination of transferrin

机译：基于微毛细管的自我参照表面等离子体共振生物传感器，用于测定转铁蛋白

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A novel self-referencing surface plasmon resonance (SPR) biosensor for detection of transferrin is demonstrated using a micro-capillary as the sensing element. The biosensor employs the SPR mode as a measuring signal and the Fabry-Perot (FP) mode as a referencing signal. The SPR mode is generated in the gold film that is coated on the outside of the capillary; instead, the FP mode is excited in the capillary, which is filled with de-ionized water. The FP mode is sensitive to temperature and insensitive to refractive index, which can be used as a referencing signal to compensate the effects caused by the temperature fluctuation. The sensor provides a high sensitivity of 1783.943 nm/RIU (refractive index unit) and a resolution of about 7.287 x 10(-5) RIU. The self-referencing biosensor was applied to measurement of transferrin protein. It can monitor the interaction of transferrin protein with anti-transferrin in real time (0-5.228 mu M). The simple and low-cost SPR sensor can be used for highly sensitive self-referencing biosensing for further investigations. (C) 2016 Optical Society of America

机译：使用微毛细管作为传感元件，对用于检测转铁蛋白的新型自我参照表面等离子体共振（SPR）生物传感器。生物传感器采用SPR模式作为测量信号和法布里 - 珀罗（FP）模式作为参考信号。 SPR模式在涂在毛细管外部的金膜中产生;相反，FP模式在毛细管中激发，毛细管填充有去离子水。 FP模式对温度敏感，对折射率不敏感，可用作参考信号以补偿由温度波动引起的效果。传感器提供1783.943nm / Riu（折射率单元）的高灵敏度，分辨率为约7.287×10（-5）Riu。将自引用生物传感器应用于转铁蛋白蛋白的测量。它可以实时监测转运蛋白与抗转铁蛋白的相互作用（0-5.228 mu m）。简单和低成本的SPR传感器可用于高度敏感的自我参考生物溶解，以进一步调查。（c）2016年美国光学学会

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《Applied optics》 |2016年第30期|共5页
作者
Chen Shimeng; Liu Yun; Liu Zigeng; Chu Shuwen; Peng Wei;
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Dalian Univ Technol Sch Phys &

Optoelect Technol 2 Linggong Rd Dalian 116024 Peoples R China;

Dalian Univ Technol Sch Phys &

Optoelect Technol 2 Linggong Rd Dalian 116024 Peoples R China;

Dalian Univ Technol Sch Phys &

Optoelect Technol 2 Linggong Rd Dalian 116024 Peoples R China;

Dalian Univ Technol Sch Phys &

Optoelect Technol 2 Linggong Rd Dalian 116024 Peoples R China;

Dalian Univ Technol Sch Phys &

Optoelect Technol 2 Linggong Rd Dalian 116024 Peoples R China;

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Micro-capillary-based self-referencing surface plasmon resonance biosensor for determination of transferrin

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