Low-cost and highly flexible intraoperative endomicroscopy system for cellular imaging

Wang Haibo; Zhang Nachuan; Zuo Siyang

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Low-cost and highly flexible intraoperative endomicroscopy system for cellular imaging

机译：用于蜂窝成像的低成本和高度灵活的术中内胚层系统

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Optical biopsy, such as probe-based endomicroscopy, represents a promising technique that can provide useful intraoperative assessment of cellular imaging instead of conventional physical biopsy and histology. Despite the merits of endomicroscopy, however, it is limited by the high cost of the optical system, difficulties in a flexible approach by a commercial probe, large-area surveillance, and tissue deformation. In this paper, we have developed a low-cost endomicroscopy system with a highly flexible fiber bundle coupled with a distal microlens, mosaicking algorithm, and robotic scanning device for obtaining large-area in vivo cellular imaging to extend the clinical application of endomicroscopy. We have demonstrated that this system can obtain good quality images from ex vivo human stomach tissue. We have also shown the potential of the system to provide a much larger field of view for optical biopsy than conventional endomicroscopy. This could greatly improve the prospects for intraoperative in vivo and in situ evaluation of cellular imaging. (C) 2018 Optical Society of America

机译：诸如基于探针的子宫内膜检查的光学活组织检查代表了有希望的技术，其可以提供对细胞成像的有用术中评估而不是传统的物理活组织检查和组织学。然而，尽管元素的优点，但是，它受到光学系统的高成本限制，难以通过商业探针，大面积监测和组织变形的柔性方法。在本文中，我们开发了一种低成本的硬质元镜系统，具有高度柔性的纤维束，其与远端微透镜，镶嵌算法和机器人扫描装置耦合，用于获得体内细胞成像的大面积，以延长内瘤的临床应用。我们已经证明，该系统可以从离体胃组织获得良好的质量图像。我们还示出了该系统的潜力，用于提供比常规的内胚层的光学活检的更大视野。这可以大大改善体内术中的前景和对细胞成像的原位评估。（c）2018年光学学会

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来源
《Applied optics》 |2018年第7期|共8页
作者
Wang Haibo; Zhang Nachuan; Zuo Siyang;
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Tianjin Univ Minist Educ Key Lab Mech Theory &

Equipment Design Tianjin 300072 Peoples R China;

Tianjin Univ Minist Educ Key Lab Mech Theory &

Equipment Design Tianjin 300072 Peoples R China;

Tianjin Univ Minist Educ Key Lab Mech Theory &

Equipment Design Tianjin 300072 Peoples R China;

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Low-cost and highly flexible intraoperative endomicroscopy system for cellular imaging

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