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首页> 外文期刊>International journal of computational biology and drug design >An in silico approach for construction of a chimeric protein, targeting virulence factors of Shigella spp.
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An in silico approach for construction of a chimeric protein, targeting virulence factors of Shigella spp.

机译：一种在嵌合蛋白的构建中的硅化方法，靶向Shigella SPP的毒力因子。

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Shigellosis is a high burden gastrointestinal disease with an increased frequency of antibiotic resistance. Type III secretion apparatus (T3SA) are conserved among different species of Shigella; and IpaD, IpaB, and IcsA proteins participate in its function. Studies indicate shiga toxin as a virulence factor has a fundamental role in hemorrhagic colitis. Bioinformatics tools were recruited for aiding this purpose. In the level of the nucleosome, sequences choosing and optimising and in the phase of the transcriptome, some prediction in associate with mRNA form, also in step of the proteome, physicochemical parameter, best stability, first to third structures and model validation were some prediction performed in assistance with in silico servers. Moreover, estimating antigenic and allergenic propensity, subcellular localisation and protein function were accomplished by bioinformatics software. Finally, these results would be beneficial in an animal model purpose for development of a pervasive candidate immunogen against Shigella spp.
机译：Shigellosis是一种高负荷胃肠疾病，抗生素抗性频率增加。 III型分泌装置（T3SA）在不同种类的令人省;和iPad，IPAB和ICSA蛋白质参与其功能。研究表明，滋阴作为毒力因子在出血性结肠炎中具有基本作用。招聘生物信息学工具以实现此目的。在核小体，序列选择和优化的序列和转录组的阶段，与mRNA形式的一些预测，也在蛋白质组的步骤中，物理化学参数，最佳稳定性，首先至第三结构和模型验证是一些预测在Silico服务器的帮助下执行。此外，通过生物信息学软件估算抗原和过敏性倾向，亚细胞定位和蛋白质功能。最后，这些结果对于动物模型目的是有益的，用于开发针对志氏菌SPP的普遍候选免疫原。

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