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首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >LOXL2 in cancer: regulation, downstream effectors and novel roles
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LOXL2 in cancer: regulation, downstream effectors and novel roles

机译：癌症中的LOXL2：调节，下游效果和新颖的角色

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Lysyl oxidase-like 2 (LOXL2) is a copper and lysine tyrosyl-quinone (LTQ)-dependent amine oxidase belonging to the lysyl oxidase (LOX) family, the canonical function of which is to catalyze the crosslinking of elastin and collagen in the extracellular matrix (ECM). Many studies have revealed that the aberrant expression of LOXL2 in multiple cancers is associated with epithelial-mesenchymal transition (EMT), metastasis, poor prognosis, chemoradiotherapy resistance, and tumor progression. LOXL2 is regulated in many ways, such as transcriptional regulation, alternative splicing, microRNA regulation, posttranslational modification, and cleavage. Beyond affecting the extracellular environment, various intracellular roles, such as oxidation and deacetylation activities in the nucleus, have been reported for LOXL2. Additionally, LOXL2 contributes to tumor cell invasion by promoting cytoskeletal reorganization. Targeting LOXL2 has become a potential therapeutic strategy to combat many types of cancers. Here, we provide an overview of the regulation and downstream effectors of LOXL2 and discuss the intracellular role of LOXL2 in cancer.
机译：赖氨酸氧化酶状2（LOX12）是属于赖氨酸氧化酶（LOX）家族的铜和赖氨酸酪氨酸醌（LTQ）依赖性胺氧化酶，其目的是催化细胞外和胶原蛋白的交联矩阵（ECM）。许多研究表明，多种癌症中LOX12的异常表达与上皮 - 间充质转换（EMT），转移，预后差，化学疗法和肿瘤进展相关。 LOX12以多种方式调节，例如转录调节，替代剪接，微窝法，后期改性和切割。除了影响细胞外环境之外，据报道，LOXL2已经报道了诸如核中的各种细胞内作用，例如核中的氧化和脱乙酰化活性。此外，LOX12通过促进细胞骨骼重组有助于肿瘤细胞侵袭。靶向LOXL2已成为打击许多类型的癌症的潜在治疗策略。在这里，我们概述了LOX12的调节和下游效应，并讨论了LOXL2在癌症中的细胞内作用。

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