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首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >Resistin: An inflammatory cytokine with multi-faceted roles in cancer
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Resistin: An inflammatory cytokine with multi-faceted roles in cancer

机译：抵抗蛋白：炎症细胞因子，癌症中具有多面体的角色

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Systemic and organ-confined inflammation has been associated with cancer development and progression. Resistin, initially described as an adipocyte-derived cytokine in mice, is mostly expressed by the macrophages in humans. It has potent pro-inflammatory properties, and its elevated serum levels are detected in cancer patients. Aberrant expression of resistin receptors is also reported in several malignancies and associated with aggressive clinicopathological features. Several lines of evidence demonstrate that resistin, acting through its different receptors, promotes tumor growth, metastasis, and chemoresistance by influencing a variety of cellular phenotypes as well as by modulating the tumor microenvironment. Racially disparate expression of resistin has also attracted much interest, considering prevalent cancer health disparities. This review discusses the aberrant expression of resistin and its receptors, its diverse downstream signaling and impact on tumor growth, metastasis, angiogenesis, and therapy resistance to support its clinical exploitation in biomarker and therapeutic development.
机译：系统和器官局限性炎症与癌症开发和进展有关。最初描述为小鼠中的脂肪细胞衍生的细胞因子的抵抗力主要由人类的巨噬细胞表达。它具有有效的促炎特性，并且在癌症患者中检测其升高的血清水平。在几种恶性肿瘤中还报告了抵抗素受体的异常表达，并与侵袭性临床病理学特征有关。几种证据表明，通过其不同的受体作用，通过影响各种细胞表型以及调节肿瘤微环境来促进肿瘤生长，转移和化学性的抵抗力。考虑普遍癌症健康差异，抗性的抗性表达也吸引了很多兴趣。本综述讨论了抗性和受体的异常表达，其各种下游信号传导和对肿瘤生长，转移，血管生成和治疗抵抗力的影响，以支持其在生物标志物和治疗发育中的临床剥削。

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