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首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >Role of gut microbiota in epigenetic regulation of colorectal Cancer
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Role of gut microbiota in epigenetic regulation of colorectal Cancer

机译：肠道微生物在结直肠癌外形调节中的作用

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Colorectal cancer (CRC) remains one of the most commonly diagnosed cancers and a leading cause of cancer-related deaths worldwide. The stepwise accumulation of epigenetic alterations in the normal colorectal epithelium has been reported to act as a driving force for the initiation and promotion of tumorigenesis in CRC. From a mechanistic standpoint, emerging evidence indicates that within the colorectal epithelium, the diverse gut microbiota can interact with host cells to regulate multiple physiological processes. In fact, recent studies have found that the gut microbiota represents a potential cause of carcinogenesis, invasion, and metastasis via DNA methylation, histone modifications, and non-coding RNAs - providing an epigenetic perspective for the connection between the gut microbiota and CRC. Herein, we comprehensively review the recent research that provides a comprehensive yet succinct evidence connecting the gut microbiota to CRC at an epigenetic level, including carcinogenic mechanisms of cancer-related microbiota, and the potential for utilizing the gut microbiota as CRC biomarkers. These scientific findings highlight a promising future for manipulating the gut microbiota to improve clinical outcomes in patients suffering from CRC.
机译：结肠直肠癌（CRC）仍然是全世界癌症相关死亡的最常见癌症之一。据报道，正常结肠直肠上皮内膜遗传改变的逐步积累作为在CRC中引发和促进肿瘤发生的驱动力。从机械角度来看，出现的证据表明，在结肠直肠上皮内，各种肠道微生物会可以与宿主细胞相互作用以调节多种生理过程。事实上，最近的研究发现，肠道微生物群代表了通过DNA甲基化，组蛋白修饰和非编码RNA的致癌，侵袭和转移的潜在原因 - 为肠道微生物肿瘤和CRC之间的连接提供表观遗传的观点。在此，我们全面回顾了最近的研究，该研究提供了一种在表观遗传水平下连接肠道微生物群至CRC的全面且简洁的证据，包括癌症相关的微生物群的致癌机制，以及利用肠道微生物作为CRC生物标志物的可能性。这些科学研究结果突出了一种有希望的未来，用于操纵肠道微生物群，以改善患有CRC的患者的临床结果。

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