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首页> 外文期刊>Bioelectromagnetics. >Effects of 2600 MHz Radiofrequency Radiation in Brain Tissue of Male Wistar Rats and Neuroprotective Effects of Melatonin
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Effects of 2600 MHz Radiofrequency Radiation in Brain Tissue of Male Wistar Rats and Neuroprotective Effects of Melatonin

机译：2600 MHz射频辐射对映射大鼠脑组织脑组织的影响及褪黑素的神经保护作用

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摘要

The debate on the biological effects of radiofrequency radiation (RFR) still continues due to differences in the design of studies (frequency, power density, specific absorption rate [SAR], exposure duration, cell, tissue, or animal type). The current study aimed to investigate the effects of 2,600 MHz RFR and melatonin on brain tissue biochemistry and histology of male rats. Thirty-six rats were divided into six groups randomly: cage-control, sham, RFR, melatonin, sham melatonin, and RFR melatonin. In RFR groups, animals were exposed to 2,600 MHz RFR for 30 days (30 min/day, 5 days/week) and the melatonin group animals were subcutaneously injected with melatonin (7 days/week, 10 mg/kg/day) for 30 days. SAR in brain gray matter was calculated as 0.44 and 0.295 W/kg for 1 and 10 g averaging, respectively. RFR exposure decreased the GSH, GSH-Px, and SOD levels and increased the MPO, MDA, and NOx levels (P < 0.005) significantly. RFR exposure also led to an increase in structural deformation and apoptosis in the brain tissue. This study revealed that exogenous high-dose melatonin could reduce these adverse effects of RFR. Limiting RFR exposure as much as possible is recommended, and taking daily melatonin supplements may be beneficial. Bioelectromagnetics. (c) 2021 Bioelectromagnetics Society
机译：由于研究设计（频率，功率密度，特定吸收率[SAR]，曝光持续时间，细胞，组织或动物型）的差异，对射频辐射（RFR）的生物效应的争论仍在继续。目前的研究旨在探讨2,600 MHz RFR和褪黑激素对脑组织生物化学和雄性大鼠组织学的影响。三十六只大鼠随机分为6组：笼控制，假，RFR，褪黑激素，假褪黑素和RFR褪黑素。在RFR基团中，将动物暴露于2,600MHz RFR持续30天（30分钟/天，5天/周），并将褪黑激素组动物皮下注射褪黑素（7天/周，10mg / kg /天）30天。脑灰质的SAR分别计算为0.44和0.295W / kg，分别为1和10g平均。 RFR曝光降低了GSH，GSH-PX和SOD水平，并显着增加了MPO，MDA和NOx水平（P <0.005）。 RFR曝光还导致脑组织结构变形和细胞凋亡的增加。本研究表明，外源性高剂量褪黑素可以降低RFR的这些不利影响。建议尽可能地限制RFR暴露，并服用每日褪黑激素补充剂可能是有益的。生物电磁学。 （c）2021生物电磁学会

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