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首页> 外文期刊>Biochemical Genetics >Association of XPA Polymorphisms Towards Lung Cancer Susceptibility and its Predictive Role in Overall Survival of North Indians
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Association of XPA Polymorphisms Towards Lung Cancer Susceptibility and its Predictive Role in Overall Survival of North Indians

机译：XPA多态性对北方印第安人整体生存的肺癌敏感性及其预测作用

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The present study investigated the role of Xeroderma pigmentosum group A ( XPA ) polymorphism ( A23G and G709A ) with lung cancer risk and its association with overall survival in North Indians. 370 cases and 370 controls were investigated to evaluate association between XPA polymorphism ( A23G and G709A ) with lung cancer risk using logistic regression analysis. A follow-up study was also conducted for 291 lung cancer cases illustrating correlation between overall survival in lung cancer patients and XPA variants. GG genotype showed an increased lung cancer risk ( p ?=?0.0007) for A23G polymorphism whereas G709A polymorphism was associated with significant protective effect in heterozygous (AG) subjects ( p ?=?0.001). When stratified according to smoking status an increased risk for lung cancer was observed for GG genotype in A23G polymorphism ( p ?=?0.0002). A poor survival in females carrying variant genotype (GG) was observed ( p ?=?0.001; MST?=?4.16?months) for A23G polymorphism. Adenocarcinoma patients with heterozygous genotype showed an increased hazard ratio ( p ?=?0.02) for A23G polymorphism. G709A was associated with a reduced hazard ratio marking a better survival among mutant females (HR 0.17; p ?=?0.05; MST?=?18.63?months). It can be concluded that A23G polymorphism might contribute to increased lung cancer risk in North Indian population emphasizing on poor survival among females. G709A polymorphism might result in protective effect in lung cancer subjects. The present study had a low sample size but it could act as reference for the large sample studies in future.
机译：本研究研究了Xeroderma Pigmerosum Group A（XPA）多态性（A23G和G709A）与肺癌风险的作用及其与北印度人整体生存的关系。 370例和370例对照进行了研究，以评估XPA多态性（A23G和G709A）与使用逻辑回归分析的肺癌风险的关联。还对291例肺癌病例进行了后续研究，说明了肺癌患者的总生存与XPA变体之间的相关性。 GG基因型显示出A23g多态性的肺癌风险（p？= 0.0007），而G709A多态性与杂合（Ag）受试者的显着保护作用有关（p？= 0.001）。当根据吸烟状态分层时，在A23G多态性中针对GG基因型观察到肺癌的风险增加（P？= 0.0002）。观察携带变体基因型（GG）的女性的存活率差（P？= 0.001; MST？=？4.16？月）对于A23G多态性。杂合基因型的腺癌患者显示出A23G多态性的危险比（P？= 0.02）增加。 G709A与危险比降低，标志着突变女性（HR 0.17; P？= 0.05; MST？= 18.63个月）。可以得出结论，A23G多态性可能导致北印度人群的肺癌风险增加，强调女性的存活差。 G709A多态性可能导致肺癌受试者的保护作用。目前的研究具有较低的样本量，但它可以作为未来大型样品研究的参考。

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