Historical origins of the discovery of mammalian nitric oxide (nitrogen monoxide) production/physiology/pathophysiology

Lancaster Jack R. Jr.

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Historical origins of the discovery of mammalian nitric oxide (nitrogen monoxide) production/physiology/pathophysiology

机译：哺乳动物一氧化氮（氮一氧化氮）生产/生理学/病理生理学发现的历史起源

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The award of the 1998 Nobel Prize in Physiology or Medicine to Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad "for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system" highlighted the discovery of center dot NO in mammals. This breakthrough also coincided with the discoveries of the role of center dot NO as a cytotoxic effector in the immune system and as an intercellular neurotransmitter in the nervous system. This brief overview describes the chronological development of this trilinear convergence in 1986-1988, including background chemistry and history of human/nitrogen oxide interactions in general.

机译：1998年1998年诺贝尔生理学或医学奖的罗伯特F.Furchgott，Louis J. Ignarro和Ferid Murad的奖项，因为心血管系统中的信号分子为其发现的一氧化物的发现“突出了在哺乳动物中的中心点否发现。这种突破还恰逢中央点No作为免疫系统中的细胞毒性效应和神经系统中的细胞间神经递质的发现。此简要概述介绍了1986年至1988年该三线性收敛的按时间顺序发展，包括一般的背景化学和人/氮氧化物相互作用的历史。

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《Biochemical Pharmacology》 |2020年第1期|共6页
作者
Lancaster Jack R. Jr.;
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作者单位

Univ Pittsburgh Sch Med Dept Pharmacol &

Chem Biol 200 Lothrop St Pittsburgh PA 15261 USA;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Nitric oxide; Endothelium-derived relaxing factor; Immune effector; Neurotransmitter cancer;

机译：一氧化氮;内皮衍生的松弛因子;免疫效应;神经递质癌症;

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1. Thai pigmented rice bran extracts inhibit production of superoxide, nitric oxide radicals and inducible nitric oxide synthase in cellular models [J] . Kedsara Junmarkho, Pintusorn Hansakul 亚太热带生物医学杂志：英文版 . 2019,第007期
2. Thai pigmented rice bran extracts inhibit production of superoxide, nitric oxide radicals and inducible nitric oxide synthase in cellular models [J] . Kedsara Junmarkho, Pintusorn Hansakul 亚太热带生物医学杂志（英文版） . 2019,第007期
3. NITROGEN(II) OXIDE (NITRIC OXIDE, NO) - ITS ORIGIN, FATE AND PHYSIOLOGICAL SIGNIFICANCE - A REVIEW [Review] [J] . Vetrovsky P., Entlicher G. Collection of Czechoslovak Chemical Communications . 1997,第9期

机译：氮氧化物（NO）-其起源，命运和生理意义-综述[综述]
4. Susceptibility of Germfree Phagocyte Oxidase- and Nitric Oxide Synthase 2-Deficient Mice, Defective in the Production of Reactive Metabolites of Both Oxygen and Nitrogen, to Mucosal and Systemic Candidiasis of Endogenous Origin [J] . Edward Balish, Thomas F. Warner, Peter J. Nicholas, Infection and immunity . 2005,第3期

机译：生殖器官的粘膜和全身念珠菌病易受感染的无胚吞噬细胞氧化酶和一氧化氮合酶2缺陷小鼠的氧和氮反应性代谢产物的产生
5. An Investigation of How Nitrogen Monoxide (NO) and Nitrogen Dioxide (NO_2) Are Produced in Oxidations by Nitric Acid (HNO3) [J] . Aliyar Mousavi Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature . 2020,第1a6期

机译：对氮氧化氮（NO）和二氧化氮（NO_2）的氧化硝酸（HNO3）产生的研究。
6. Nitric Oxide Production from Surface Recombination of Oxygen and Nitrogen Atoms [C] . D. Pejakovic, J. Marschall, L. Duan, AIAA Aerospace Sciences Meeting and Exhibit . 2008

机译：氧和氮原子的表面复合产生一氧化氮
7. Nitric oxide in health and disease: Physiology, pathophysiology, and clinical measurement [D] . Angelo, Michael. 2008

机译：一氧化氮在健康和疾病中的作用：生理学，病理生理学和临床测量
8. Susceptibility of Germfree Phagocyte Oxidase- and Nitric Oxide Synthase 2-Deficient Mice Defective in the Production of Reactive Metabolites of Both Oxygen and Nitrogen to Mucosal and Systemic Candidiasis of Endogenous Origin [O] . Edward Balish, Thomas F. Warner, Peter J. Nicholas, 2005

机译：生殖器官的粘膜和全身念珠菌病易感的无胚吞噬细胞氧化酶和一氧化氮合酶2缺陷小鼠对氧气和氮气的反应性代谢产物的产生都有缺陷。
9. Susceptibility of Germfree Phagocyte Oxidase- and Nitric Oxide Synthase 2-Deficient Mice, Defective in the Production of Reactive Metabolites of Both Oxygen and Nitrogen, to Mucosal and Systemic Candidiasis of Endogenous Origin [O] . Balish, Edward, Warner, Thomas F., Nicholas, Peter J., 2005

机译：生殖器官的粘膜和全身念珠菌病易感的无胚吞噬细胞氧化酶和一氧化氮合酶2缺陷小鼠，对氧气和氮气的反应性代谢产物的产生都有缺陷。
10. Claremont Atmospheric Free-Radical Study: Measurements of Formaldehyde, HydrogenPeroxide, Nitric Acid, Nitrous Acid, Peroxyacetyl Nitrate, Nitrogen Dioxide, Nitrogen Oxides, Ozone, Carbon Monoxide, Hydrocarbons (C1-C12), and Carbonyl Compounds (C1-Benzald [R] . Mackay, G. I. 1994

机译：Claremont大气自由基研究：甲醛，氢过氧化物，硝酸，亚硝酸，过氧乙酰硝酸盐，二氧化氮，氮氧化物，臭氧，一氧化碳，碳氢化合物（C1-C12）和羰基化合物（C1-Benzald）的测量

Historical origins of the discovery of mammalian nitric oxide (nitrogen monoxide) production/physiology/pathophysiology

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