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首页> 外文期刊>Biochemical Pharmacology >Potential effects of noxious chemical-containing fine particulate matter on oral health through reactive oxygen species-mediated oxidative stress: Promising clues
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Potential effects of noxious chemical-containing fine particulate matter on oral health through reactive oxygen species-mediated oxidative stress: Promising clues

机译：通过反应性氧物种介导的氧化应激对含氧化学含细颗粒物质对口腔健康的潜在影响：有希望的线索

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摘要

Nowadays, air pollution which is dominated by fine particulate matter with aerodynamic diameter less than or equal to 2.5 mu m resulting from rapid industrialization and urbanization combined with population explosion has become more and more severe problem to mankind and the whole planet because of its diversity of deleterious effects. The latest data estimated that exposure to fine particulate matter, or PM2.5, contributes to approximately 4 million deaths worldwide due to cardiopulmonary conditions such as heart disease and stroke, respiratory infections, chronic lung disease and lung cancer. During recent years, there has been growing concern about the adverse effects of this global threat on oral health which is one of key components of general health and quality of life. Although a few studies have reported such possible association, the findings are still far from conclusion. Moreover, the underlying mechanisms remain unclear. To our knowledge, the analysis of literature regarding this scope has yet been published. Thus, current work systematically assesses existing evidences on the potential association between exposure to PM2.5 and the development of various oral diseases as well as figures out the plausible paradigm of PM2.5-induced damages in the oral cavity through its toxic chemical constituents along with its ability to induce oxidative stress via reactive oxygen species production. This might partially provide the clues for new research ideas and progression in the field of oral health.
机译：如今，由于快速工业化和城市化与人口爆炸结合的空气动力学直径，具有小于或等于2.5亩的空气动力学直径的空气污染与人口爆炸相结合，因此由于其多样性而与人类和整个星球变得越来越严重的问题有害效果。由于心肺和中风，呼吸道感染，慢性肺病和肺癌等心肺病症，最新数据估计暴露于细颗粒物质或PM2.5，为全球约400万人死亡导致全球约400万人死亡。近年来，对这种全球威胁对口腔健康的不利影响，这是越来越关注的是，这是一般健康和生活质量的关键组成部分之一。虽然一些研究报告了这种可能的协会，但调查结果仍然没有结论。此外，潜在机制仍然不清楚。据我们所知，有关此范围的文献尚未发表。因此，目前的工作系统地评估了暴露于PM2.5之间的潜在关联的现有证据，以及各种口服疾病的发展，以及通过其毒性化学成分通过其毒性化学成分的PM2.5引起的PM2.5引起的损伤的可粘性范例。其能够通过反应性氧物种生产诱导氧化应激。这可能部分提供了口腔健康领域的新研究思想和进展的线索。

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