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The biology and therapeutic management of melanoma brain metastases

机译：黑色素瘤脑转移的生物学和治疗管理

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The recent years have seen significant progress in the development of systemic therapies to treat patients with advanced melanoma. Use of these new treatment modalities, which include immune checkpoint inhibitors and small molecule BRAF inhibitors, lead to increased overall survival and better outcomes. Although revolutionary, these therapies are often less effective against melanoma brain metastases, and frequently the CNS is the major site of treatment failure. The development of brain metastases remains a serious complication of advanced melanoma that is associated with significant morbidity and mortality. New approaches to both prevent the development of brain metastases and treat established disease are urgently needed. In this review we will outline the mechanisms underlying the development of melanoma brain metastases and will discuss how new insights into metastasis biology are driving the development of new therapeutic strategies. Finally, we will describe the latest data from the ongoing clinical trials for patients with melanoma brain metastases. (C) 2018 Elsevier Inc. All rights reserved.
机译：近年来，在系统疗法的发展中治疗先进黑素瘤患者的显着进展。使用这些新的治疗方式，包括免疫检查点抑制剂和小分子BRAF抑制剂，导致总生存率增加和更好的结果。虽然革命性，这些疗法往往对黑色素瘤脑转移效果较小，并且频繁的CNS是治疗失败的主要部位。脑转移的发展仍然是具有显着发病率和死亡率的先进黑素瘤的严重并发症。迫切需要预防脑转移和治疗疾病的新方法是迫切需要的。在本综述中，我们将概述黑素瘤脑转移的发展的机制，并将讨论转移生物学的新见解是如何推动新的治疗策略的发展。最后，我们将描述来自黑色素瘤脑转移患者的正在进行的临床试验中的最新数据。 （c）2018年Elsevier Inc.保留所有权利。

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