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Antimicrobials offered from nature: Peroxidase-catalyzed systems and their mimics

机译：从性质提供的抗微生物剂：过氧化物酶催化系统及其模仿

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摘要

The control of antimicrobial resistance requires the development of novel antimicrobial alternatives and naturally occurring peroxidase-catalyzed systems may be of great value in this era of emerging antimicrobial resistance. In the peroxidase system, a peroxidase enzyme catalyzes the oxidation of a halide/pseudohalide, at the expense of hydrogen peroxide, to generate reactive products with broad antimicrobial properties. The appropriate use of peroxidase systems needs a better understanding of the identities and properties of the generated antimicrobial oxidants, specific targets in bacterial cells, their mode of action and the factors favoring or limiting their activity. Here, the ABCs (antibacterial activity, bacterial "backtalk" and cytotoxicity) of these systems and their mimics are discussed. Particular attention is paid to the concomitant use of thiocyanate and iodide dual substrates in peroxidase/peroxidase-free systems with implications on their antimicrobial activity. This review also provides a summary of actual applications of peroxidase systems as bio-preservatives in oral healthcare, milk industry, food/feed specialties and related products, mastitis and wound treatment; lastly, this review points to opportunities for further research and potential applications.
机译：抗微生物抗性的控制需要开发新颖的抗微生物替代品，并且天然存在的过氧化物酶催化系统在新出现的抗微生物抗性的时代可能具有很大的价值。在过氧化物酶系统中，过氧化物酶催化卤化物/假织物的氧化，以亚氧化氢以产生具有广泛抗微生物性质的反应性产物。适当使用过氧化物酶系统需要更好地理解所产生的抗微生物氧化剂的身份和性质，细菌细胞中的特异性靶标，它们的作用方式和有利或限制其活动的因素。这里，讨论了这些系统及其模拟物的ABCs（抗菌活性，细菌“倒退”和细胞毒性）。特别注意在过氧化物酶/过氧化物酶的系统中伴随着硫氰酸酯和碘化物双底物，具有对其抗微生物活性的影响。本综述还提供过氧化物酶系统作为生物防腐剂在口腔医疗保健，牛奶工业，食品/饲料专业以及相关产品，乳腺炎和伤口治疗中的实际应用的概述;最后，本综述指出了进一步研究和潜在应用的机会。

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