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The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications

机译：细胞一氧化氮和硫化氢输送系统的演化景观：一种自定义药物的新时代

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摘要

Nitric oxide (NO) and hydrogen sulfide (H2S) are industrial toxins or pollutants; however, both are produced endogenously and have important biological roles in most mammalian tissues. The recognition that these gasotransmitters have a role in physiological and pathophysiological processes has presented opportunities to harness their intracellular effects either through inhibition of their production; or more commonly, through inducing their levels and or delivering them by various modalities. In this review article, we have focused on an array of NO and H2S donors, their hybrids with other established classes of drugs, and the various engineered delivery platforms such a fibers, polymers, nanoparticles, hydrogels, and others. In each case, we have reviewed the rationale for their development.
机译：一氧化氮（NO）和硫化氢（H2S）是工业毒素或污染物; 然而，两者都是内源性的，并且在大多数哺乳动物组织中具有重要的生物学作用。 识别这些汽油转化器在生理和病理生理过程中具有作用的作用，通过抑制其生产，呈现了利用其细胞内效应的机会; 或者更常见，通过诱导其水平和通过各种方式传递它们。 在本综述文章中，我们专注于一系列NO和H2S捐赠者，他们的杂种与其他已既定的药物类别，以及各种工程送货平台这样的纤维，聚合物，纳米粒子，水凝胶等。 在每种情况下，我们已经审查了他们的发展的理由。

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