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首页> 外文期刊>Biochemical Pharmacology >Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes
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Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes

机译：一氧化氮和硫化氢的碳水化合物代谢调节：糖尿病中的影响

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摘要

Nitric oxide (NO) and hydrogen sulfide (H2S) are two gasotransmitters that are produced in the human body and have a key role in many of the physiological activities of the various organ systems. Decreased NO bioavailability and deficiency of H2S are involved in the pathophysiology of type 2 diabetes and its complications. Restoration of NO levels have favorable metabolic effects in diabetes. The role of H2S in pathophysiology of diabetes is however controversial; H2S production is decreased during development of obesity, diabetes, and its complications, suggesting the potential therapeutic effects of H2S. On the other hand, increased H2S levels disturb the pancreatic beta-cell function and decrease insulin secretion. In addition, there appear to be important interactions between NO and H2S at the levels of both biosynthesis and signaling pathways, yet clear an insight into this relationship is lacking. H2S potentiates the effects of NO in the cardiovascular system as well as NO release from its storage pools. Likewise, NO increases the activity and the expression of H2S-generating enzymes. Inhibition of NO production leads to elimination/attenuation of the cardioprotective effects of H2S. Regarding the increasing interest in the therapeutic applications of NO or H2S-releasing molecules in a variety of diseases, particularly in the cardiovascular disorders, much is to be learned about their function in glucose/insulin metabolism, especially in diabetes. The aim of this review is to provide a better understanding of the individual and the interactive roles of NO and H2S in carbohydrate metabolism.
机译：一氧化氮（NO）和硫化氢（H2S）是在人体中产生的两个汽油转化器，并且在各种器官系统的许多生理活动中具有关键作用。没有减少生物利用度，H2S的缺乏涉及2型糖尿病的病理生理学及其并发症。恢复没有水平在糖尿病中具有有利的代谢效应。 H2S在糖尿病病理生理学中的作用是有争议的;在肥胖，糖尿病及其并发症的发展过程中，H2S生产减少，表明H2S的潜在治疗效果。另一方面，增加的H 2 S水平扰乱胰腺β细胞功能并降低胰岛素分泌。此外，在生物合成和信号通路的水平之间似乎和H2S之间的重要相互作用似乎缺乏对这种关系的洞察力。 H2S增强了NO在心血管系统中的影响，也没有从其储存池中释放。同样，不增加H 2 S产生酶的活性和表达。抑制不产生的产生导致H2S的心脏保护作用的消除/衰减。关于在各种疾病中不含或H2S释放分子的较高的兴趣，特别是在心血管障碍中，尤其是糖尿病的葡萄糖/胰岛素代谢的功能很多。本综述的目的是提供更好地了解碳水化合物代谢中NO和H2S的个体和互动作用。

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