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首页> 外文期刊>Biochemical Pharmacology >The role of Kruppel-like factor 8 in cancer biology: Current research and its clinical relevance
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The role of Kruppel-like factor 8 in cancer biology: Current research and its clinical relevance

机译：Kruppel样因子8在癌症生物学中的作用：当前的研究及其临床相关性

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摘要

Cancer is one of the leading causes of mortality worldwide, ranked second after heart disease. Despite recent advancements in diagnosis and treatment, there are still numerous problems associated with cancer progression, disease recurrence, and therapeutic resistance that are partially explored. Several studies have recently revealed that Kruppel-like factor 8 (KLF8) regulates transcription of genes linked with diverse biological processes, including proliferation, epithelial to mesenchymal transition (EMT), migration, invasion, and inflammation. KLF8 is expressed ubiquitously in mammalian cells, and its aberrant expression has been manifested with several cancer types. Earlier studies demonstrated the crucial role of KLF8 in DNA repair and resistance to apoptosis in numerous cancer types. Hence, studying the function of KLF8 from the perspective of cancer progression and therapy resistance would help develop a new therapeutic avenue. In this review, we summarize the clinical relevance of KLF8 expression in various malignancies, focusing on recent updates in EMT, cellular signaling, and cancer stem cells. We also address the contribution of KLF8 in development, DNA repair, chemoresistance, and its clinical utility as a predictive biomarker.
机译：癌症是全世界死亡率的主要原因之一，在心脏病患者后排名第二。尽管近期诊断和治疗进展，但仍存在与部分探索的癌症进展，疾病复发和治疗性相关的许多问题。最近有几项研究表明，Kruppel样因子8（KLF8）调节与不同生物过程相关的基因的转录，包括增殖，下皮对间充质转换（EMT），迁移，侵袭和炎症。 KLF8在哺乳动物细胞中普遍表达，并且其异常表达已经表现出几种癌症类型。早期的研究表明KLF8在DNA修复和抗细胞凋亡中的关键作用在许多癌症类型中。因此，从癌症进展和治疗抗性的角度研究KLF8的功能将有助于开发一种新的治疗大道。在本综述中，我们总结了KLF8表达在各种恶性肿瘤中的临床相关性，其侧重于EMT，细胞信号和癌症干细胞的最近更新。我们还解决了KLF8在开发，DNA修复，化学抑制和其临床实用性作为预测生物标志物的贡献。

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