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首页> 外文期刊>Biochemical Pharmacology >Neuropolybin: A new antiseizure peptide obtained from wasp venom
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Neuropolybin: A new antiseizure peptide obtained from wasp venom

机译：神经聚蛋白：从黄蜂毒液中获得的新的抗肿瘤肽

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Epilepsy accounts for one of the most serious neurological disorders, and its treatment remains a challenge, due to high cost and harmful side effects. Bioactive molecules extracted from arthropod venoms are considered a promising therapy since these compounds are known for their highly selective and potent profiles. The purpose of this study was to identify and characterize the potential antiseizure effect of the peptide Ppnp7, extracted from the venom of the social wasp Polybia paulista, and also the effect of the bioinspired peptide, named Neuropolybin, in the same parameters. Additionally, we also evaluated the electroencephalographic (EEG) profile in the PTZ-induced acute seizures in animals treated with Neuropolybin, and potential adverse effects of both peptides in general spontaneous activity (Open Field analysis). Interestingly, Ppnp7 and Neuropolybin showed a noteworthy antiseizure effect in rats and mice, respectively. Curves of protection against the maximum seizure were obtained for both peptides, and EEG records demonstrated that Neuropolybin protected 80% of animals from tonic-clonic seizures when applied with a dose of 3 nmol (an approximate Ppnp7 ED50 found in rats). Neuropolybin and Ppnp7 did not cause changes in the general spontaneous activity of the animals in any of the doses evaluated. Therefore, this study demonstrated how compounds isolated from wasps' venom may be essential resources in the search for new drugs, and can also be considered valuable therapeutic and biotechnological tools for the study and future treatment of epileptic disorders.
机译：由于高成本和有害的副作用，癫痫患者占最严重的神经系统疾病之一，其治疗仍然是一个挑战。从节肢动物毒液中提取的生物活性分子被认为是有希望的疗法，因为这些化合物是以高精度和有效的曲线已知的。本研究的目的是鉴定和表征肽PPNP7的潜在抗肿瘤效果，从社会黄金族Paulista的毒液中提取，也是生物悬浮肽，名为神经聚萘的效果，在相同的参数中。另外，我们还评估了在用神经聚萘蛋白处理的动物中的PTZ诱导的急性癫痫发作中的脑电图（EEG）轮廓，以及肽在一般自发性活性（开放场分析）中的潜在不利影响。有趣的是，PPNP7和神经聚蛋白分别在大鼠和小鼠中表现出了值得注意的抗肿瘤作用。对肽获得肽的保护曲线，肽和EEG记录表明，当用3 Nmol施用剂量（大鼠中发现的近似PPNP7 ED50）时，EEG记录被认为是从滋补克隆癫痫发作的80％的动物。 Neuropolybin和PPNP7没有导致动物在任何评价的任何剂量中的一般自发活动的变化。因此，本研究证明了来自WASPS的毒液中分离的化合物是如何寻找新药的基本资源，也可以被视为对癫痫病毒的研究和未来治疗有价值的治疗和生物技术工具。

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