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首页> 外文期刊>Biological & pharmaceutical bulletin >Effect of Continuous Pharmacist Interventions on Pain Control and Side Effect Management in Outpatients with Cancer Receiving Opioid Treatments
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Effect of Continuous Pharmacist Interventions on Pain Control and Side Effect Management in Outpatients with Cancer Receiving Opioid Treatments

机译：连续药剂干预措施对接受阿片类药物治疗癌外门诊患者疼痛控制和副作用管理的影响

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For improving the QOL of patients diagnosed with cancer, early palliative care is recommended, aiming to minimize pain and opioid-induced side effects. Herein, we evaluated the effect of continuous interventions for pain management and opioid-induced side effects in outpatients with cancer. Pharmacists continuously performed interventions on patients on their hospital visits, starting from the first visit for opioid introduction to intervention via telephone. We recorded their pain patterns and intensities, use of rescue doses, and types and degrees of side effects during these interventions. The physicians were suggested appropriate recommendations for increased doses or alternative opioids when the pharmacists considered the analgesic dose should be titrated. During the study period, palliative care pharmacists conducted 105 interviews for 27 patients (male: 19 and female: 8) with cancer pain. Pain intensities significantly decreased after the pharmacists' continuous intervention, including those from telephone interviews, with their appropriate recommendations and increased opioid doses. Side effects such as nausea and constipation increased or remained unaffected even after the intervention, likely due to the increased opioid doses. Approximately 90% of recommendations for pain control were accepted by the physicians and helped to control the pain intensities. Before starting physician consultations, pharmacists informed the patients that adequate pain control and side effect management were achievable through regular interviews, wherein patient symptoms were monitored and patients received detailed explanations of pharmaceutical care and courteous and continuous counseling.
机译：为了改善患有癌症的患者的QoL，建议早期姑息治疗，旨在最大限度地减少疼痛和阿片类药物诱导的副作用。在此，我们评估了连续干预措施对疼痛管理和阿片类药物诱导的癌症患者的副作用的影响。药剂师连续对患者进行医院访问的干预，从首次访问Opioid通过电话进行干预介绍。我们记录了他们的疼痛模式和强度，使用救援剂量，以及这些干预期间的类型和副作用程度。当药剂师认为应滴定镇痛剂量时，医生们提出适当的建议，增加剂量或替代阿片类药物。在研究期间，姑息治疗药剂师对27名患者（男性：19和女性：8）进行了105次访谈，癌症疼痛。在药剂师的持续干预后，包括从电话采访的人的痛苦，疼痛强度显着下降，其适当的建议和增加的阿片类药物。副作用如恶心和便秘甚至在干预之后增加或保持不受影响，可能由于阿片类药物的增加。医生接受大约90％的疼痛控制建议，并帮助控制疼痛强度。在开始医生咨询之前，药剂师通过经常访谈获知患者可通过经常访谈实现充足的疼痛控制和副作用管理，其中监测患者症状，患者接受了药物护理和礼貌和不断咨询的详细解释。

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