Protein import by the mitochondrial disulfide relay in higher eukaryotes

YannikFinger; JanRiemer

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Protein import by the mitochondrial disulfide relay in higher eukaryotes

机译：由线粒体二硫化物继电器在高等真核生物中导入蛋白质

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摘要

The proteome of the mitochondrial intermembrane space (IMS) contains more than 100 proteins, all of which are synthesized on cytosolic ribosomes and consequently need to be imported by dedicated machineries. The mitochondrial disulfide relay is the major import machinery for soluble proteins in the IMS. Its major component, the oxidoreductase MIA40, interacts with incoming substrates, retains them in the IMS, and oxidatively folds them. After this reaction, MIA40 is reoxidized by the sulfhydryl oxidase augmenter of liver regeneration, which couples disulfide formation by this machinery to the activity of the respiratory chain. In this review, we will discuss the import of IMS proteins with a focus on recent findings showing the diversity of disulfide relay substrates, describing the cytosolic control of this import system and highlighting the physiological relevance of the disulfide relay machinery in higher eukaryotes.

机译：线粒体膜间空间（IMS）的蛋白质组含有超过100种蛋白质，所有这些蛋白质在细胞骨核糖体上合成，因此需要由专用机械进口。线粒体二硫化物继电器是IMS中可溶性蛋白质的主要进口机械。其主要成分，氧化还原酶MIA40与进入的基材相互作用，在IMS中保持它们，并氧化折叠它们。在该反应之后，通过肝再生的巯基氧化酶增强剂来环氧化，这将该机器与呼吸链的活性相结合的二硫化物形成。在本综述中，我们将讨论IMS蛋白的进口，重点是最近显示二硫化物继电器底物的多样性，描述该进口系统的细胞溶质控制，并突出了较高真核生物中二硫化物继电器机械的生理相关性。

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《Biological chemistry》 |2020年第7期|共15页
作者
YannikFinger; JanRiemer;
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作者单位

Institute for Biochemistry Redox Biochemistry University of Cologne Zülpicher Str. 47a/R. 3.49;

Department of Chemistry Institute for Biochemistry Redox Biochemistry University of Cologne and;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
disulfide relay; MIA40; mitochondrial import; proteasomal degradation;

机译：二硫化物继电器;MIA40;线粒体进口;蛋白酶体降解;

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1. Exploring the contribution of the mitochondrial disulfide relay system to Parkinson's disease: the PINK1/CHCHD4 interplay [J] . Giuseppe Arena, Nazanine Modjtahedi, Rejko Kruger 中国神经再生研究（英文版） . 2021,第011期
2. TOM9.2 Is a Calmodulin-Binding Protein Critical for TOM Complex Assembly but Not for Mitochondrial Protein Import in Arabidopsis thaliana [J] . Nargis Parvin, Ute C.Vothknecht, Fatima Chigri, 分子植物（英文版） . 2017,第004期
3. HP30-2, a mitochondrial PRAT protein for import of signal sequence-less precursor proteins in Arabidopsis thaliana [J] . Claudia Rossig, John Gray, Oscar Valdes, 植物学报（英文版） . 2017,第008期
4. MitoCPR: a novel protective mechanism in response to mitochondrial protein import stress [J] . Mingzhu Tang, Xuling Luo, Zhen Huang, 生物化学与生物物理学报：英文版 . 2018,第010期
5. Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay [J] . Markus Habich, Silja Lucia Salscheider, Lena Maria Murschall, Cell Reports . 2019,第3期

机译：通过亚稳定的二硫键连接的复合物进行矢量导入，允许质量控制步骤，并通过线粒体二硫键进行导入
6. Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay [J] . Markus Habich, Silja Lucia Salscheider, Lena Maria Murschall, Cell Reports . 2019,第3期

机译：通过亚稳定的二硫键连接的复合物进行矢量导入，允许质量控制步骤，并通过线粒体二硫键进行导入
7. Mitochondrial Disulfide Relay: Redox-regulated Protein Import into the Intermembrane Space [J] . Johannes Herrmann, Jan Riemer The Journal of biological chemistry . 2012,第7期

机译：线粒体二硫化物继电器：氧化还原蛋白质进口到内膜空间
8. Mitochondrial Protein Import Driven by Molecular Chaperones [C] . T. Endo International Congress on Genes, Gene Families and Isozymes(ICGGFI); 20050917-21; Shanghai(CN) . 2005

机译：分子伴侣驱动的线粒体蛋白质进口
9. Role of protein-protein interactions in mitochondrial protein import, cholesterol transport and steroid biosynthesis. [D] . Rone, Malena Beth. 2010

机译：蛋白质相互作用在线粒体蛋白质输入，胆固醇转运和类固醇生物合成中的作用。
10. Mitochondrial Disulfide Relay: Redox-regulated Protein Import into the Intermembrane Space [O] . Johannes M. Herrmann, Jan Riemer 2012

机译：线粒体二硫键：氧化还原调节蛋白导入膜间空间。
11. Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system [O] . Groß, Dominik P., Burgard, Caroline A., Reddehase, Silvia, 2011

机译：线粒体Ccs1包含结构性二硫键，这对于通过二硫键中继系统导入这种非常规底物至关重要
12. The Force Exerted by the Membrane Potential During Protein Import into the Mitochondrial Matrix [R] . Shariff, Karim, Ghosal, Sandip, Matouschek, Andreas 2002

机译：蛋白质导入线粒体基质过程中膜电位的作用力

Protein import by the mitochondrial disulfide relay in higher eukaryotes

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