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首页> 外文期刊>Biomaterials Science >Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy
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Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

机译：用于单波激活的光热和光动力学协同疗法的铁蛋白中石卟啉钠的超高负荷

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摘要

In this work, a potent photosensitizer, sinoporphyrin sodium (DVDMS), was loaded into RGD-modified ferritin (R-Fn) nanocages by a rapid, scalable and versatile approach for imaging guided photodynamic and photothermal (PTT/PDT) co-therapy. The resulting nanocomposite formed a well-defined nanocage with a photosensitizer loading capacity as high as 66.67 wt%, which far exceeds those reported previously. The bioengineered protein nanocage-based nanotheranostics exhibits a remarkably improved tumor treatment effect over DVDMS with good biocompatibility and the potential of clinical translation.
机译：在这项工作中，通过快速，可伸缩和通用的方法将有效的光敏剂，中骨蛋白钠（DVDMS）加载到RGD改性的铁蛋白（R-FN）纳米纳米中，用于成像引导的光动力和光热（PTT / PDT）共同治疗。 所得纳米复合材料形成明确定义的纳米病，光敏剂负载能力高达66.67wt％，该负载量远远超过先前报道的那些。 生物工程化蛋白纳米病的纳米烷基因型纳米蛋白在具有良好的生物相容性和临床翻译潜力的DVDM上具有显着改善的肿瘤治疗效果。

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  • 来源
    《Biomaterials Science》 |2017年第8期|共5页
  • 作者

    Huang Chao; Chu Chengchao; Wang Xiaoyong; Lin Huirong; Wang Junqing; Zeng Yun; Zhu Wenzhen; Wang Yi-Xiang J.; Liu Gang;

  • 作者单位

    Huazhong Univ Sci &

    Technol Tongji Hosp Tongji Med Coll Dept Radiol Wuhan 430030 Hubei Peoples R China;

    Xiamen Univ Sch Publ Hlth State Key Lab Mol Vaccinol &

    Mol Diagnost Xiamen 361102 Peoples R China;

    Xiamen Univ Sch Publ Hlth State Key Lab Mol Vaccinol &

    Mol Diagnost Xiamen 361102 Peoples R China;

    Xiamen Univ Sch Publ Hlth State Key Lab Mol Vaccinol &

    Mol Diagnost Xiamen 361102 Peoples R China;

    Chinese Univ Hong Kong Dept Imaging &

    Intervent Radiol Shatin Hong Kong Peoples R China;

    Xiamen Univ Sch Publ Hlth State Key Lab Mol Vaccinol &

    Mol Diagnost Xiamen 361102 Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Hosp Tongji Med Coll Dept Radiol Wuhan 430030 Hubei Peoples R China;

    Chinese Univ Hong Kong Dept Imaging &

    Intervent Radiol Shatin Hong Kong Peoples R China;

    Xiamen Univ Sch Publ Hlth State Key Lab Mol Vaccinol &

    Mol Diagnost Xiamen 361102 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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