Strategies for the design of nanoparticles: starting with long-circulating nanoparticles, from lab to clinic

Wang Ruyi; Zhang Zhongtao; Liu Bowen; Xue Jingwei; Liu Fulei; Tang Tongzhong; Liu Wenyuan; Feng Feng; Qu Wei

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Strategies for the design of nanoparticles: starting with long-circulating nanoparticles, from lab to clinic

机译：纳米粒子设计的策略：从长循环纳米颗粒开始，从实验室到诊所

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Short half-life is one of the main causes of drug attrition in clinical development, which also leads to the failure of many leading compounds and hits to become drug candidates. Nowadays, nanomaterials have been applied to drug development to address this problem. In fact, the clinical application of nanoparticles (NPs) is severely limited due to their rapid elimination by the reticuloendothelial system (RES) in vivo. In this paper, we aim to summarize representative strategies on prolonging the circulation time for bridging the gap between excellent pharmaceutics and proper half-life and encourage clinical translation.

机译：短半衰期是临床开发中吸毒疲劳的主要原因之一，也导致许多领先的化合物和命中的失败成为毒品候选者。如今，纳米材料已被应用于药物开发以解决这个问题。实际上，由于它们在体内的网状内皮系统（RES）的快速消除，纳米颗粒（NPS）的临床应用严重限制。在本文中，我们的目标是总结代表性的策略，延长了延长了弥合优秀药剂学和适当半衰期之间的差距的流通时间，并鼓励临床翻译。

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来源
《Biomaterials Science》 |2021年第10期|共17页
作者
Wang Ruyi; Zhang Zhongtao; Liu Bowen; Xue Jingwei; Liu Fulei; Tang Tongzhong; Liu Wenyuan; Feng Feng; Qu Wei;
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China Pharmaceut Univ Dept Nat Med Chem Nanjing 211198 Peoples R China;

China Pharmaceut Univ Dept Nat Med Chem Nanjing 211198 Peoples R China;

China Pharmaceut Univ Dept Nat Med Chem Nanjing 211198 Peoples R China;

Taian City Cent Hosp Joint Lab China Pharmaceut Univ &

Taian City Cent Tai An 271000 Shandong Peoples R China;

Taian City Cent Hosp Joint Lab China Pharmaceut Univ &

Taian City Cent Tai An 271000 Shandong Peoples R China;

China Pharmaceut Univ Dept Nat Med Chem Nanjing 211198 Peoples R China;

China Pharmaceut Univ Dept Pharmaceut Anal Nanjing 210009 Peoples R China;

China Pharmaceut Univ Dept Nat Med Chem Nanjing 211198 Peoples R China;

China Pharmaceut Univ Dept Nat Med Chem Nanjing 211198 Peoples R China;

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正文语种 eng
中图分类分子生物学;
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Strategies for the design of nanoparticles: starting with long-circulating nanoparticles, from lab to clinic

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