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首页> 外文期刊>Biomaterials Science >Peptide functionalized upconversion/NIR II luminescent nanoparticles for targeted imaging and therapy of oral squamous cell carcinoma
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Peptide functionalized upconversion/NIR II luminescent nanoparticles for targeted imaging and therapy of oral squamous cell carcinoma

机译：肽官能化上变化/ NIR II发光纳米颗粒，用于靶向成像和口腔鳞状细胞癌的治疗

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摘要

Early diagnosis is critical and challenging for tongue squamous cell carcinoma (TSCC), which is a kind of tumor with high malignancy, poor prognosis, and a high incidence of invasion and metastasis. In this research, dual-modal optical imaging rare earth nanoparticle (RENP) probes with peptide functionalization are designed for targeted TSCC imaging and therapy. RENP@C@Au (UCA) with enhanced red upconversion luminescence (UCL) and near infrared II (NIR II) imaging intensity is designed by metal and codopant modulation, and the two peaks at about 650 nm and 1064 nm of Nd ions are relatively stable with less quenching and suitable for luminescence bioimaging. Then, the cMBP peptide targeted to Cal 27 TSCC cells with highly expressed c-MET proteins is combined with UCA. Compared with human's normal cells of MCF-10A, other tumor cell lines such as A549 and HeLa, together with mice tumor cells of 4T1, the designed probe has targeted imaging and therapy to Cal 27. The final in vivo experiment shows that the probe with high NIR II luminescence signals is not easy to retain when injected into the tail vein, indicating its potential precise clinical application for the diagnosis and therapy of TSCC.
机译：早期诊断是舌鳞状细胞癌（TSCC）的关键和挑战，这种肿瘤是一种具有高恶性，预后差和侵袭和转移的高发病率。在该研究中，双模型光学成像稀土纳米粒子（RENP）探针具有肽官能化的探针，用于靶向TSCC成像和治疗。具有增强的红色上转换发光（UCL）和近红外线II（NIR II）成像强度的Renp @ AU（UCA）由金属和划分剂调制设计，并且相对较650nm和1064nm的两个峰相对稳定稳定，淬火，适用于发光生物成像。然后，将靶向CA127 TSCC细胞具有高表达的C-Met蛋白的CMBP肽与UCA结合。与人类正常的MCF-10A细胞相比，其他肿瘤细胞系如A549和HeLa，以及4T1的小鼠肿瘤细胞，设计的探针具有靶向成像和治疗。体内实验中的决赛显示探头在注射到尾静脉时，高NIR II发光信号不易保留，表明其精确的临床应用于TSCC的诊断和治疗。

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  • 来源
    《Biomaterials Science》 |2021年第3期|共8页
  • 作者

    Lin Bi; Wu Jun; Wang Yanxing; Sun Song; Yuan Ying; Tao Xiaofeng; Lv Ruichan;

  • 作者单位

    Xidian Univ Sch Life Sci &

    Technol Engn Res Ctr Mol &

    Neuro Imaging Minist Educ Xian 710071 Shanxi Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Peoples Hosp 9 Sch Med Dept Radiol Shanghai 200011 Peoples R China;

    Xidian Univ Sch Life Sci &

    Technol Engn Res Ctr Mol &

    Neuro Imaging Minist Educ Xian 710071 Shanxi Peoples R China;

    Xidian Univ Sch Life Sci &

    Technol Engn Res Ctr Mol &

    Neuro Imaging Minist Educ Xian 710071 Shanxi Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Peoples Hosp 9 Sch Med Dept Radiol Shanghai 200011 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Peoples Hosp 9 Sch Med Dept Radiol Shanghai 200011 Peoples R China;

    Xidian Univ Sch Life Sci &

    Technol Engn Res Ctr Mol &

    Neuro Imaging Minist Educ Xian 710071 Shanxi Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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