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Fluorinated chitosan-mediated intracellular catalase delivery for enhanced photodynamic therapy of oral cancer

机译:氟化壳聚糖介导的细胞内过缩酶输送,用于增强口腔癌的光动力学治疗

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摘要

A pH-responsive fluorinated chitosan-chlorin e6 (FC-Ce6) was employed here for the intracellular delivery of catalase to relieve the hypoxic micro-environment. Upon simple mixing, FC-Ce6 and catalase co-assemble to form stable nanoparticles, which show a greatly improved cross-membrane penetration capacity compared with catalase alone or nonfluorinated CS-Ce6/catalase nanoparticles. Under catalase catalysis, a high concentration of intracellular H2O2 can be transformed into O-2. Upon irradiation, due to the continuous formation of cytotoxic singlet oxygen (O-1(2)), our nanoparticles showed superior anti-cancer activity in contrast to free Ce6 and nonfluorinated CS-Ce6/catalase nanoparticles. Our study proposes an effective intracellular catalase delivery system to overcome hypoxia for enhanced PDT against oral cancer.
机译:这里使用pH-响应氟化壳聚糖-氯丙酸咖啡E6(FC-CE6)用于细胞内递送过氧化氢酶以缓解缺氧微环境。 在简单的混合,FC-CE6和过氧酶共组装以形成稳定的纳米颗粒,其与单独的过氧化氢酶或非氟化的CS-CE6 /过氧化氢酶纳米颗粒相比具有大大提高的跨膜穿透能力。 在过氧化氢酶催化下,高浓度的细胞内H 2 O 2可以转化为O-2。 在照射时,由于细胞毒素氧(O-1(2))的连续形成,我们的纳米颗粒与游离CE6和非氟化的CS-CE6 /过氧化氢酶纳米颗粒相反,抗癌活性优异。 我们的研究提出了一种有效的细胞内过氧化氢酶输送系统,以克服缺氧以增强针对口腔癌的PDT。

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  • 来源
    《Biomaterials Science》 |2021年第3期|共5页
  • 作者单位

    Shanghai Jiao Tong Univ Shanghai Peoples Hosp 9 Shanghai Key Lab Stomatol Coll Stomatol Sch Med Natl Clin Res Ctr Oral Dis Dept Oral &

    Maxillofacial Head &

    Neck Oncol Dept Shanghai 200011 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Mol Engn Chiral Drugs Sch Chem &

    Chem Engn Shanghai 200240 Peoples R China;

    Shandong Univ Sch &

    Hosp Stomatol Cheeloo Coll Med Dept Oral &

    Maxillofacial Surg Jinan Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Mol Engn Chiral Drugs Sch Chem &

    Chem Engn Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Mol Engn Chiral Drugs Sch Chem &

    Chem Engn Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Peoples Hosp 9 Shanghai Key Lab Stomatol Coll Stomatol Sch Med Natl Clin Res Ctr Oral Dis Dept Oral &

    Maxillofacial Head &

    Neck Oncol Dept Shanghai 200011 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Mol Engn Chiral Drugs Sch Chem &

    Chem Engn Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Peoples Hosp 9 Shanghai Key Lab Stomatol Coll Stomatol Sch Med Natl Clin Res Ctr Oral Dis Dept Oral &

    Maxillofacial Head &

    Neck Oncol Dept Shanghai 200011 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

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