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首页> 外文期刊>Biomaterials Science >Graphene-based materials: the key for the successful application of pHEMA as a blood-contacting device
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Graphene-based materials: the key for the successful application of pHEMA as a blood-contacting device

机译：基于石墨烯的材料：将PHEMA成功应用作为血液接触装置的关键

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Thrombosis and infection are the leading causes of blood-contacting device (BCD) failure, mainly due to the poor performance of existing biomaterials. Poly(2-hydroxyethyl methacrylate) (pHEMA) has excellent hemocompatibility but the weak mechanical properties impair its use as a bulk material for BCD. As such, pHEMA has been explored as a coating, despite the instability and difficulty of attachment to the underlying polymer compromise its success. This work describes the hydrogel composites made of pHEMA and graphene-based materials (GBM) that meet the biological and mechanical requirements for a standalone BCD. Five GBM differing in thickness, oxidation degree, and lateral size were incorporated in pHEMA, revealing that only oxidized-GBM can reinforce pHEMA. pHEMA/oxidized-GBM composites are cytocompatible and prevent the adhesion of endothelial cells, blood platelets, and bacteria (S. aureus), thus maintaining pHEMA's anti-adhesive properties. As a proof of concept, the thrombogenicity of the tubular prototypes of the best formulation (pHEMA/Graphene oxide (GO)) was evaluated in vivo, using a porcine arteriovenous-shunt model. pHEMA/GO conduits withstand the blood pressure and exhibit negligible adhesion of blood components, revealing better hemocompatibility than ePTFE, a commercial material for vascular access. Our findings reveal pHEMA/GO, a synthetic and off-the-shelf hydrogel, as a preeminent material for the design of blood-contacting devices that prevent thrombosis and bacterial adhesion.
机译：血栓形成和感染是血液接触装置（BCD）失效的主要原因，主要是由于现有生物材料的性能差。聚（2-羟乙基甲基丙烯酸甲酯）（PHEMA）具有优异的血液化，但弱机械性能损害其用作BCD的散装材料。因此，尽管对潜在的聚合物损害其成功，但Phema已被探索为涂层，尽管仍然存在于潜在的聚合物的附着。这项工作描述了由PhEMA和基于石墨烯的材料（GBM）制成的水凝胶复合材料，其符合独立BCD的生物和机械要求。厚度，氧化程度和横向尺寸不同的5 GBM含有PHEMA，揭示仅氧化-GBM可以增强PHEMA。 PHEMA /氧化-GBM复合材料是细胞锁定的，防止内皮细胞，血小板和细菌的粘附（S.UUREUS），从而保持PHEMA的抗粘性性能。作为概念的证据，使用猪动静脉分流模型在体内评价最佳配方的管状原型的血栓形成性（Phema /石墨烯氧化物（GO））。 PHEMA / GO管道可承受血压并表现出可忽略的血液成分粘附，揭示比EPTFE更好的血液振动性，这是一种用于血管进入的商业材料。我们的研究结果揭示了Phema / Go，一种合成和现成的水凝胶，作为血液接触装置设计的卓越材料，防止血栓形成和细菌粘附。

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  • 来源
    《Biomaterials Science》 |2021年第9期|共16页
  • 作者

    Andreia T. Pereira; Patricia C. Henriques; Karl H. Schneider; Ana L. Pires; Andre M. Pereira; Maria Cristina L. Martins; Fernao D. Magalhaes; Helga Bergmeister; Ines C. Goncalves;

  • 作者单位

    INEB - Instituto de Engenharia Biomedica Universidade do Porto Portugal;

    INEB - Instituto de Engenharia Biomedica Universidade do Porto Portugal;

    Center for Biomedical Research Medical University of Vienna Vienna Austria;

    IFIMUP - Instituto de Fisica de Materiais Avancados Nanotecnologias e Fotonica Departamento de Fisica e Astronomia Faculdade de Ciencias Universidade do Porto Portugal;

    IFIMUP - Instituto de Fisica de Materiais Avancados Nanotecnologias e Fotonica Departamento de Fisica e Astronomia Faculdade de Ciencias Universidade do Porto Portugal;

    INEB - Instituto de Engenharia Biomedica Universidade do Porto Portugal;

    LEPABE - Laboratory for Process Engineering Environment Biotechnology and Energy Faculty of Engineering University of Porto Portugal;

    Center for Biomedical Research Medical University of Vienna Vienna Austria;

    INEB - Instituto de Engenharia Biomedica Universidade do Porto Portugal;

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  • 中图分类 计量学;
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