A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression

Zhang Huiwen; Lu Fei; Pan Wei; Ge Yegang; Cui Bingjie; Gong Shaohua; Li Na; Tang Bo

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A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression

机译：一种双催化纳米反应器，用于协同化学动力学 - 饥饿治疗肿瘤转移抑制

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Tumor metastasis is extremely deadly for cancer patients and developing effective treatments for deep metastatic tumors remains a major challenge. In this study, we demonstrated a dual-catalytic nanoreactor for tumor metastasis suppression by synergistic Fenton reaction activated chemodynamic therapy (CDT) and glucose oxidase (GOx) initiated starvation therapy. GOx on the surface of hollow mesoporous silica nanoparticles can catalyze the decomposition of intratumoral glucose to generate gluconic acid and H2O2, while Fe3O4 nanoparticles as a Fenton reaction catalyst can in situ catalyze H2O2 to produce highly toxic hydroxyl radicals (OH). The oxygen-carrying perfluorohexane (PFC) in the hole of the hollow structures can alleviate the hypoxic environment and promote dual-catalytic reactions. After being disguised by the cancer cell membrane, the delivery efficiency and biological safety of the nanoreactor were effectively improved. The nanoreactor can realize sequential glucose depletion and OH aggregation, which effectively suppress tumor metastasis with negligible side effects.

机译：肿瘤转移对于癌症患者来说是非常致命的，并且对深层转移性肿瘤的有效治疗仍然是一个重大挑战。在这项研究中，通过协同芬顿反应活化的化学动力学治疗（CDT）和葡萄糖氧化酶（GOX）引发饥饿治疗，我们证明了一种用于肿瘤转移抑制的双催化纳米反应器。中空介孔二氧化硅纳米粒子表面的GOX可以催化肿瘤内葡萄糖的分解产生葡糖和H2O2，而FE3O4纳米颗粒作为FENTON反应催化剂可以原位催化H2O2以产生高毒羟基自由基（OH）。中空结构孔中的携带含氧全氟己烷（PFC）可以缓解缺氧环境并促进双催化反应。在癌细胞膜伪装后，有效改善纳米反应器的输送效率和生物安全性。纳米反应器可以实现连续葡萄糖耗尽和OH聚集，从而有效地抑制肿瘤转移，副作用可忽略不计。

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《Biomaterials Science》 |2021年第10期|共7页
作者
Zhang Huiwen; Lu Fei; Pan Wei; Ge Yegang; Cui Bingjie; Gong Shaohua; Li Na; Tang Bo;
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作者单位

Shandong Normal Univ Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Inst Mol &

Nano Sci Minist Educ Collaborat Innovat Ctr Functionalized Jinan 250014 Peoples R China;

Shandong Normal Univ Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Inst Mol &

Nano Sci Minist Educ Collaborat Innovat Ctr Functionalized Jinan 250014 Peoples R China;

Shandong Normal Univ Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Inst Mol &

Nano Sci Minist Educ Collaborat Innovat Ctr Functionalized Jinan 250014 Peoples R China;

Shandong Normal Univ Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Inst Mol &

Nano Sci Minist Educ Collaborat Innovat Ctr Functionalized Jinan 250014 Peoples R China;

Shandong Normal Univ Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Inst Mol &

Nano Sci Minist Educ Collaborat Innovat Ctr Functionalized Jinan 250014 Peoples R China;

Shandong Normal Univ Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Inst Mol &

Nano Sci Minist Educ Collaborat Innovat Ctr Functionalized Jinan 250014 Peoples R China;

Shandong Normal Univ Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Inst Mol &

Nano Sci Minist Educ Collaborat Innovat Ctr Functionalized Jinan 250014 Peoples R China;

Shandong Normal Univ Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Inst Mol &

Nano Sci Minist Educ Collaborat Innovat Ctr Functionalized Jinan 250014 Peoples R China;

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机译：仿生纳米反应器，用于协同化学激发光动力疗法和饥饿疗法对抗肿瘤转移
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机译：通过氧化应激扩增和级联Fenton反应的肿瘤靶向超分子催化纳米反应器进行协同化疗/化学动力学治疗
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机译：乳腺癌转移中肿瘤驱动的免疫抑制机制。
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机译：仿生纳米反应器用于协同化学激发光动力疗法和饥饿疗法对抗肿瘤转移
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机译：一种用于协同化学光动力疗法和饥饿治疗肿瘤转移的仿生纳米反应器
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机译：KaI1基因抑制肿瘤转移的机制;最终报告2004年1月12日至2008年1月11日

A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression

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