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首页> 外文期刊>Biomaterials Science >A flexible fibrous membrane based on copper(ii) metal-organic framework/poly(lactic acid) composites with superior antibacterial performance
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A flexible fibrous membrane based on copper(ii) metal-organic framework/poly(lactic acid) composites with superior antibacterial performance

机译：一种柔性纤维膜，基于铜（II）金属 - 有机骨架/聚（乳酸）复合材料，具有优异的抗菌性能

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摘要

A flexible antibacterial fibrous membrane employing high antibacterial efficiency has great potential in healthcare applications. Herein, a three-dimensional copper(ii) metal-organic framework [Cu-2(CA)(H2O)(2), Cu-MOF-1] and poly(lactic acid) (PLA) composite fibrous membrane was prepared through a facile electrospinning method. The sphere-like Cu-MOF-1 was rapidly synthesized by a microwave-assisted hydrothermal reaction of Cu(ii) salts with citric acid (H(4)CA) in the presence of polyvinyl pyrrolidone (PVP). The surface morphology, thermal stability, mechanical properties and hydrophilicity test of the as-prepared Cu-MOF-1/PLA fibrous membrane were studied systematically. Compared with commercial copper nanoparticles (Cu-NPs), citric acid and copper citrate, Cu-MOF-1 showed higher antibacterial properties with the bacteriostatic rates of 97.9% and 99.3% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively, when the used dose was 250 mu g mL(-1). The Cu-MOF-1/PLA fibrous membrane also exhibited outstanding bactericidal activities against E. coli and S. aureus with the antibacterial rates up to 99.3% and 99.8%, respectively. Mechanism investigation indicated that the slowly released Cu2+ ions could destroy the microenvironment of bacteria cells and destroy the integrity and permeability of the cell membrane, leading to enzyme inactivation. Therefore, the as-prepared flexible fibrous membrane will advance progress toward developing a broad spectrum antibacterial textile for healthcare protection related applications.
机译：柔性抗菌纤维膜，采用高抗菌效率在医疗保健应用中具有很大的潜力。在此，通过A通过a制备三维铜（II）金属 - 有机框架[Cu-2（Ca）（2），Cu-mof-1]和聚（乳酸）（PLA）复合纤维状纤维膜。易于静电纺丝法。在聚乙烯吡咯烷酮（PVP）存在下，通过Cu（II）盐的微波辅助水热反应通过Cu（II）盐的微波辅助水热反应迅速合成球形Cu-Mof-1。系统形态，制备的Cu-Mof-1 / PLA纤维膜的表面形态，热稳定性，机械性能和亲水性试验。与商业铜纳米颗粒（Cu-NPS）相比，柠檬酸和柠檬酸铜，Cu-Mof-1显示出较高的抗菌性能，抑菌性能为97.9％和99.3％，对大肠杆菌（大肠杆菌）和金黄色葡萄球菌（S.）当使用的剂量为250μgmm（-1）时，AURES）分别分别。 Cu-Mof-1 / PLA纤维膜还表现出对大肠杆菌和金黄色葡萄球菌的突出杀菌活性，抗菌率分别高达99.3％和99.8％。机制研究表明，缓慢释放的Cu2 +离子可能破坏细菌细胞的微环境并破坏细胞膜的完整性和渗透性，导致酶失活。因此，制备的柔性纤维膜将推进朝向发育广谱抗菌纺织品的进展，用于医疗保健保护相关应用。

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  • 来源
    《Biomaterials Science》 |2021年第10期|共9页
  • 作者

    Liu Zhao; Ye Junwei; Rauf Abdul; Zhang Siqi; Wang Guangyao; Shi Suqi; Ning Guiling;

  • 作者单位

    Dalian Univ Technol Sch Chem Engn State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Liaoning Peoples R China;

    Dalian Univ Technol Sch Chem Engn State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Liaoning Peoples R China;

    Univ Management &

    Technol Sch Sci Dept Chem CII Johar Town Lahore 54770 Pakistan;

    Dalian Univ Technol Sch Chem Engn State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Liaoning Peoples R China;

    Dalian Univ Technol Sch Chem Engn State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Liaoning Peoples R China;

    Dalian Univ Technol Sch Chem Engn State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Liaoning Peoples R China;

    Dalian Univ Technol Sch Chem Engn State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Liaoning Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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