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首页> 外文期刊>Biomaterials Science >Prevention of pulmonary air leaks using a biodegradable tissue-adhesive fiber sheet based on Alaska pollock gelatin modified with decanyl groups
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Prevention of pulmonary air leaks using a biodegradable tissue-adhesive fiber sheet based on Alaska pollock gelatin modified with decanyl groups

机译：使用基于癸基的阿拉斯加波兰洛蛋白的可生物降解的组织 - 粘性纤维片预防肺部空气泄漏

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摘要

Tissue adhesives have been widely used in surgery to treat pulmonary air leaks. However, conventional adhesives have poor interfacial strength under wet conditions. To overcome this clinical problem, we modified Alaska pollock-derived gelatin to include decanyl (C10) groups (C10-ApGltn) and used electrospinning to create a tissue-adhesive fiber sheet (AdFS). C10-AdFS showed higher burst strength when adhering to porcine pleura compared with a sheet of original ApGltn (Org-ApGltn). Hematoxylin-eosin-stained sections after burst experiments reveal that a dense C10-AdFS layer remained on the surface of the porcine pleura. The effect of the degree of C10 modification of ApGltn on the burst strength was evaluated. ApGltn with a C10 modification ratio of 13 mol% amino groups (13C10-AdFS) exhibited the highest burst strength. Furthermore, from ex vivo experiments with extracted rat lung, 13C10-AdFS exhibited a higher burst strength (41 cm H2O) than Org-AdFS. The decanyl groups in 13C10-AdFS interacted with the hydrophobic proteins and the lipid bilayers of the cells, resulting in the high interfacial strength between 13C10-AdFS and the pleura. Moreover, 13C10-AdFS samples implanted subcutaneously in the backs of rats were completely degraded within 21 days without any severe inflammation. These results show that 13C10-AdFS is a promising adhesive material for the treatment of pulmonary air leaks.
机译：组织粘合剂已广泛用于手术以治疗肺部空气泄漏。然而，常规粘合剂在潮湿条件下具有差的界面强度差。为了克服这种临床问题，我们改性阿拉斯加花草衍生的明胶以包括癸基（C10）基团（C10-APGLTN）并用过静电纺丝以产生组织粘性纤维片（ADF）。与原始APGLTN（ORG-APGLTN）相比，C10-ADF在粘附到猪胸膜时显示出更高的突发强度。爆发实验后的血杂志 - 嗜酸盐染色部分揭示了致密的C10-ADFS层留在猪胸膜的表面上。评估了APG1TN对突发强度的C10改性程度的影响。具有13mol％氨基（13C10-ADF）的C10改性比的APGLTN表现出最高的突发强度。此外，从具有提取的大鼠肺的离体实验，13C10-ADF表现出比ORG-ADF的更高突发强度（41cm H 2 O）。 13C10-ADF中的脱癸基与细胞的疏水蛋白和脂质双层相互作用，导致13C10-ADF和胸膜之间的高界面强度。此外，在大鼠背面植入的13C10-ADFS样品在21天内完全降解而没有任何严重的炎症。这些结果表明，13C10-ADF是用于治疗肺部空气泄漏的有前途的粘合剂材料。

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  • 来源
    《Biomaterials Science》 |2021年第3期|共13页
  • 作者

    Ichimaru Hiroaki; Mizuno Yosuke; Chen Xi; Nishiguchi Akihiro; Taguchi Tetsushi;

  • 作者单位

    Univ Tsukuba Grad Sch Pure &

    Appl Sci 1-1-1 Tennodai Tsukuba Ibaraki 3058577 Japan;

    Univ Tsukuba Grad Sch Pure &

    Appl Sci 1-1-1 Tennodai Tsukuba Ibaraki 3058577 Japan;

    Natl Inst Mat Sci Res Ctr Funct Mat Polymers &

    Biomat Field 1-1 Namiki Tsukuba Ibaraki 3050044 Japan;

    Natl Inst Mat Sci Res Ctr Funct Mat Polymers &

    Biomat Field 1-1 Namiki Tsukuba Ibaraki 3050044 Japan;

    Univ Tsukuba Grad Sch Pure &

    Appl Sci 1-1-1 Tennodai Tsukuba Ibaraki 3058577 Japan;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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