Genipin-cross-linked hydrogels based on biomaterials for drug delivery: a review

Yibin Yu; Shuo Xu; Sanming Li; Hao Pan

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Genipin-cross-linked hydrogels based on biomaterials for drug delivery: a review

机译：基于生物材料的Genipin-交联水凝胶：审查

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Genipin is a naturally occurring nontoxic cross-linker, which has been widely used for drug delivery due to its excellent biocompatibility, admirable biodegradability and stable cross-linked attributes. These advantages led to its extensive application in the fabrication of hydrogels for drug delivery. This review describes the physicochemical characteristics and pharmacological activities of genipin and attempts to elucidate the detailed mechanisms of the cross-linking reaction between genipin and biomaterials. The current article entails a general review of the different biomaterials cross-linked by genipin: chitosan and its derivatives, collagen, gelatin, etc. The genipin-cross-linked hydrogels for various pharmaceutical applications, including ocular drug delivery, buccal drug delivery, oral drug delivery, anti-inflammatory drug delivery, and antibiotic and antifungal drug delivery, are reported. Finally, the future research directions and challenges of genipin-cross-linked hydrogels for pharmaceutical applications are also discussed in this review.

机译：Genipin是一种天然存在的无毒交联剂，其由于其优异的生物相容性，令人透气的生物降解性和稳定的交联属性而被广泛用于药物递送。这些优点导致其在制造水凝胶中的广泛应用中的药物递送。该综述描述了Genipin的物理化学特征和药理活性，并试图阐明Genipin和生物材料之间交联反应的详细机制。目前的文章需要一般审查由Genipin：壳聚糖及其衍生物，胶原蛋白，明胶等交联的不同生物材料的一般性审查。全脂交联水凝胶用于各种药物应用，包括眼药递送，口腔药物递送，口服报道了药物递送，抗炎药物递送和抗生素和抗真菌药物递送。最后，在本综述中还讨论了对药物应用的Genipin-Crons-Constled水凝胶的未来研究方向和挑战。

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《Biomaterials Science》 |2021年第5期|共15页
作者
Yibin Yu; Shuo Xu; Sanming Li; Hao Pan;
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School of Pharmacy Liaoning University Shenyang 110036 China;

School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China;

School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China;

School of Pharmacy Liaoning University Shenyang 110036 China;

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正文语种 eng
中图分类计量学;
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Genipin-cross-linked hydrogels based on biomaterials for drug delivery: a review

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