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Design and application of inorganic nanoparticles for sonodynamic cancer therapy

机译：初始动力癌治疗无机纳米粒子的设计与应用

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摘要

As an alternative to photodynamic therapy (PDT), ultrasound-triggered tumor sonodynamic therapy (SDT) has garnered significant attention, owing to its high tissue penetration, few side effects, and reliable patient compliance. A sonosensitizer is the most important component in SDT, and high-quantum-yield safe sonosensitizers are crucial for SDT. Existing sonosensitizers mainly include organic sonosensitizers and inorganic sonosensitizers. Organic sonosensitizers, mainly some small dye molecules, have been widely studied. However, organic sonosensitizers have limited utility owing to their poor stability, rapid blood clearance, and potential phototoxicity. In contrast, inorganic sonosensitizers have stable chemical properties, long circulation time in the blood and can effectively reduce phototoxicity. in addition to their utilization as sonosensitizers, some inorganic nanoparticles can also operate as carriers for delivering organic sonosensitizers, effectively overcoming the inherent shortcomings of organic small-molecule sonosensitizers. This review mainly focuses on inorganic nanomaterial-based SDT, the possible mechanisms of SDT, and newly developed inorganic sonosensitizers, as well as the challenges and possible solutions associated with their clinical translation are introduced.
机译：作为光动力治疗（PDT）的替代方案，超声触发的肿瘤超声动力治疗（SDT）由于其高组织渗透，副作用和可靠的患者遵守而获得了显着的关注。超声胶酶是SDT中最重要的组成部分，高量子产量安全超声胶质剂对SDT至关重要。现有的超声胶质胶质剂主要包括有机超声胶质剂和无机超声胶质剂。有机超声胶质剂，主要是一些小染料分子，已被广泛研究。然而，由于其稳定性，快速的血液清除率差，血液清除率和潜在的光毒性，有机超声胶质剂具有有限的效用。相比之下，无机超声胶囊剂具有稳定的化学性质，血液中长的循环时间，可以有效地减少光毒性。除了他们作为超声溶胶的使用外，一些无机纳米颗粒还可以作为携带有机超声胶质剂的载体操作，有效地克服有机小分子超声胶囊化剂的固有缺点。本综述主要侧重于无机纳米材料SDT，SDT的可能机制，以及新开发的无机超声胶质剂，以及与其临床翻译相关的挑战和可能的解决方案。

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  • 来源
    《Biomaterials Science》 |2021年第6期|共16页
  • 作者

    Sun Lihong; Wang Ping; Zhang Jinxia; Sun Yang; Sun Suhui; Xu Menghong; Zhang Lulu; Wang Shumin; Liang Xiaolong; Cui Ligang;

  • 作者单位

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Ultrasound Beijing 100191 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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