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首页> 外文期刊>Biomaterials Science >In situ formation of nanocomposite double-network hydrogels with shear-thinning and self-healing properties
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In situ formation of nanocomposite double-network hydrogels with shear-thinning and self-healing properties

机译：原位形成纳米复合双网络水凝胶，具有剪切稀疏和自愈性能

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Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges remain, including the time-consuming preparation and the lack of shear-thinning and self-healing properties. Here, our approach to developing versatile ncDN hydrogels is through the use of multiple interfacial crosslinking chemistries (i.e., noncovalent interactions of electrostatic interaction and hydrogen bonds as well as dynamic covalent interactions of imine bonds and boronate ester bonds) and surface functionalized nanomaterials (i.e. phenylboronic acid modified reduced graphene oxide (PBA-rGO)). PBA-rGO was used as a multivalent gelator to further crosslink the two polymer chains (i.e. triethylene glycol-grafted chitosan (TEG-CS) and polydextran aldehyde (PDA)) in DN hydrogels, forming the TEG-CS/PDA/PBA-rGO ncDN hydrogels in seconds. The microstructures (i.e. pore size) and properties (i.e. rheological, mechanical, and swelling properties) of the ncDN hydrogels can be simply modulated by changing the amount of PBA-rGO. The dynamic bonds in the polymeric network provided the shear-thinning and self-healing properties to the ncDN hydrogels, allowing the hydrogels to be injected and molded into varied shapes as well as self-repair the damaged structure. Besides, the designed TEG-CS/PDA/PBA-rGO ncDN hydrogels were cytocompatible and also exhibited antibacterial activity. Taken together, we hereby provide a nanomaterial approach to fabricate a new class of ncDN hydrogels with tailorable networks and favorite properties for specific applications.
机译：最近引入纳米复合双网络水凝胶（NCDN水凝胶）以解决传统DN水凝胶的局限，例如网络结构缺乏多样性和限制功能。然而，仍然存在两个挑战，包括耗时的准备和缺乏剪切变薄和自我愈合性质。在这里，我们对发展多功能NCDN水凝胶的方法是通过使用多种界面交联化学品（即静电相互作用和氢键的非共价相互作用以及亚胺键和硼酸酯键的动态共价相互作用和表面官能化的纳米材料（即苯硼（即苯硼）酸改性的石墨烯氧化物（PBA-RGO））。 PBA-Rgo用作多价凝胶剂，以进一步交联在DN水凝胶中的两个聚合物链（即三甘醇接枝的壳聚糖（TEG-CS）和聚醛醛（PDA）），形成TEG-CS / PDA / PBA-RGO ncdn水凝胶以秒为单位。通过改变PBA-RGO的量，可以简单地调节NCDN水凝胶的微观结构（即孔径）和性质（即流变，机械和溶胀性质）。聚合物网络中的动态键在NCDN水凝胶中提供了剪切稀释和自愈合性质，使水凝胶注入并模塑成变化的形状以及自修复损坏的结构。此外，设计的TEG-CS / PDA / PBA-RGO NCDN水凝胶是细胞锁定的，也表现出抗菌活性。我们在一起，我们在此提供一种纳米材料方法，用于制造新的NCDN水凝胶，具有可定制的网络和特定应用的最喜欢的特性。

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