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Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery

机译：间充质干细胞膜涂层纳米粒子的最新进展，用于增强药物递送

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摘要

Studies of nanomedicine have achieved dramatic progress in recent decades. However, the main challenges that traditional nanomedicine has to overcome include low accumulation at target sites and rapid clearance from the blood circulation. An interesting approach using cell membrane coating technology has emerged as a possible way to overcome these limitations, owing to the enhanced targeted delivery and reduced immunogenicity of cell membrane moieties. Mesenchymal stem cell (MSC) therapy has been investigated for treating various diseases, ranging from inflammatory diseases to tissue damage. Recent studies with engineered modified MSCs or MSC membranes have focused on enhancing cell therapeutic efficacy. Therefore, bioengineering strategies that couple synthetic nanoparticles with MSC membranes have recently received much attention due to their homing ability and tumor tropism. Given the various membrane receptors on their surfaces, MSC membrane-coated nanoparticles are an effective method with selective targeting properties, allowing entry into specific cells. Here, we review recent progress on the use of MSC membrane-coated nanoparticles for biomedical applications, particularly in the two main antitumor and anti-inflammatory fields. The combination of a bioengineered cell membrane and synthesized nanoparticles presents a wide range of possibilities for the further development of targeted drug delivery, showing the potential to enhance the therapeutic efficacy for treating various diseases.
机译：纳米医生近几十年来实现了戏剧性的进展。然而，传统纳米医生必须克服的主要挑战包括在靶位点和血液循环的快速间隙中的低积聚。由于增强的靶向递送和细胞膜部分的免疫原性降低了这种局限性，使用细胞膜涂层技术的一种有趣方法作为克服这些限制的可能方法。研究了间充质干细胞（MSC）治疗治疗各种疾病，从炎症疾病到组织损伤。近期具有工程改性MSC或MSC膜的研究重点是增强细胞治疗效果。因此，由于其归巢能力和肿瘤的热带，夫妇与MSC膜结合合成纳米颗粒的生物工程策略最近受到了很多关注。考虑到它们表面上的各种膜受体，MSC膜涂覆的纳米颗粒是具有选择性靶向性质的有效方法，允许进入特定细胞。在这里，我们审查了最近使用MSC膜涂覆的纳米颗粒进行生物医学应用的进展，特别是在两个主要抗肿瘤和抗炎田中。生物工程细胞膜和合成纳米颗粒的组合呈现了进一步发展靶向药物递送的各种可能性，显示出增强治疗各种疾病的治疗效果的可能性。

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  • 来源
    《Biomaterials Science》 |2021年第4期|共16页
  • 作者

    Wang Mian; Xin Yuanfeng; Cao Hao; Li Wanlu; Hua Yifei; Webster Thomas J.; Zhang Chao; Tang Wenjie; Liu Zhongmin;

  • 作者单位

    Tongji Univ Translat Med Ctr Stem Cell Therapy Res Ctr Translat Med Dept Cardiol Shanghai Peoples R China;

    Tongji Univ Translat Med Ctr Stem Cell Therapy Res Ctr Translat Med Dept Cardiol Shanghai Peoples R China;

    Tongji Univ Translat Med Ctr Stem Cell Therapy Res Ctr Translat Med Dept Cardiol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Biomed Engn Shanghai 200030 Peoples R China;

    Tongji Univ Translat Med Ctr Stem Cell Therapy Res Ctr Translat Med Dept Cardiol Shanghai Peoples R China;

    Northeastern Univ Dept Chem Engn 360 Huntington Ave Boston MA 02115 USA;

    Tongji Univ Translat Med Ctr Stem Cell Therapy Res Ctr Translat Med Dept Cardiol Shanghai Peoples R China;

    Tongji Univ Translat Med Ctr Stem Cell Therapy Res Ctr Translat Med Dept Cardiol Shanghai Peoples R China;

    Tongji Univ Translat Med Ctr Stem Cell Therapy Res Ctr Translat Med Dept Cardiol Shanghai Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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