• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomaterials Science >A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration
【24h】

A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration

机译：一种简单的水凝胶支架，具有可注射性，粘附性和骨再生活性的活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Numerous efforts have been made to prepare hydrogels with injectability, adhesivity and osteogenic activity for bone regeneration. However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production. In this study, a multifunctional hydrogel with a binary component is prepared for bone regeneration. Dopamine (DA) is first grafted to alginate (Alg) by amidation reaction to give Alg-DA. Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA. Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA. In addition, the catechol groups endow the hydrogel with significant tissue adhesivity. More importantly, the strontium ions endow the hydrogel with osteogenic activity. As indicated by animal experiments, the strontium containing hydrogel scaffolds help to treat rat bone defects within 8 weeks compared to hydrogels without strontium and control groups. This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
机译：已经进行了许多努力，制备水凝胶，其具有可注射性，粘附性和骨再生活性的可注射性，粘附性和成骨活性。然而，由于其复杂的化学组成，具有这些特性的当前水凝胶在临床翻译中具有有限的应用，这导致批量生产难以困难。在该研究中，为骨再生制备具有二元组分的多官能水凝胶。首先通过酰胺化反应将多巴胺（DA）接枝以进行藻酸盐（ALG），得到ALG-DA。然后通过将锶离子与藻类水溶液混合，利用锶离子与ALG -DA的羧基之间的动态离子键合来制备可注射水凝胶。在体内的模拟氧化条件下，由于ALG-DA对不含儿茶酚基团的存在，可注射水凝胶可以形成稳定的化学交联。此外，儿茶酚基团赋予水凝胶，具有显着的组织粘附性。更重要的是，锶离子赋予水凝胶与骨质发生活性。如动物实验所示，含有水凝胶支架的锶有助于与没有锶和对照组的水凝胶相比在8周内治疗大鼠骨缺陷。通过使用二元组分构建的这种简单的水凝胶已经实现了几种必要的功能，并且预期将用作临床应用中的骨组织工程的支架。

著录项

  • 来源
    《Biomaterials Science》 |2021年第3期|共13页
  • 作者

    Zhang Hongjie; Cai Qiuquan; Zhu Yanhui; Zhu Weipu;

  • 作者单位

    Zhejiang Univ MOE Key Lab Macromol Synth &

    Functionalizat Dept Polymer Sci &

    Engn Hangzhou 310027 Zhejiang Peoples R China;

    Zhejiang Univ MOE Key Lab Macromol Synth &

    Functionalizat Dept Polymer Sci &

    Engn Hangzhou 310027 Zhejiang Peoples R China;

    Zhejiang Univ MOE Key Lab Macromol Synth &

    Functionalizat Dept Polymer Sci &

    Engn Hangzhou 310027 Zhejiang Peoples R China;

    Zhejiang Univ MOE Key Lab Macromol Synth &

    Functionalizat Dept Polymer Sci &

    Engn Hangzhou 310027 Zhejiang Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号