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Design of nanoengineered antibacterial polymers for biomedical applications

机译：生物医学应用纳米工程抗菌聚合物设计

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摘要

Pathogenic bacteria have become global threats to public health. Since the advent of antibiotics about 100 years ago, their use has been embraced with great enthusiasm because of their effective treatment of bacterial infections. However, the evolution of pathogenic bacteria with resistance to conventional antibiotics has resulted in an urgent need for the development of a new generation of antibiotics. The use of antimicrobial polymers offers the promise of enhancing the efficacy of antimicrobial agents. Of the various antibacterial polymers that effectively eradicate pathogenic bacteria, those that are nanoengineered have garnered significant research interest in their design and biomedical applications. Because of their high surface area and high reactivity, these polymers show greater antibacterial activity than conventional antibacterial agents, by inhibiting the growth or destroying the cell membrane of pathogenic bacteria. This review summarizes several strategies for designing nanoengineered antibacterial polymers, explores the factors that affect their antibacterial properties, and examines key features of their design. It then comments briefly on the future prospects for nanoengineered antibacterial polymers. This review thus provides a feasible guide to developing nanoengineered antibacterial polymers by presenting both broad and indepth bench research, and it offers suggestions for their potential in biomedical applications.
机译：致病细菌已成为对公共卫生的全球威胁。自从大约100年前的抗生素的出现以来，他们的使用是由于他们有效治疗细菌感染而受到极大的热情。然而，致病性对常规抗生素的致病细菌的演变导致了迫切需要开发新一代抗生素。抗微生物聚合物的使用提供了提高抗微生物剂的疗效的承诺。在有效地消除致病性细菌的各种抗菌聚合物中，那些纳米工理的抗菌聚合物在其设计和生物医学应用中获得了显着的研究兴趣。由于其高表面积和高反应性，这些聚合物通过抑制致病细菌的生长或破坏细胞膜来显示比常规抗菌剂更大的抗菌活性。本综述总结了设计纳米工程抗菌聚合物的几种策略，探讨了影响其抗菌特性的因素，并检查其设计的关键特征。然后，评论纳入抗菌聚合物的未来前景简要评注。因此，通过展示广泛和印度长凳研究，该综述提供了一种可行的导向纳米工程抗菌聚合物，并为其在生物医学应用中提供了潜力的建议。

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  • 来源
    《Biomaterials Science》 |2020年第24期|共16页
  • 作者

    Qinggele Borjihan; Alideertu Dong;

  • 作者单位

    College of Chemistry and Chemical Engineering Inner Mongolia University Hohhot 010021 People's Republic of China;

    College of Chemistry and Chemical Engineering Inner Mongolia University Hohhot 010021 People's Republic of China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 计量学;
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