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首页> 外文期刊>Biomaterials Science >Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties
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Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties

机译：过氧化物酶和UIO-66-NH2 /壳聚糖复合膜的氧化酶模拟活性，用于抗菌性能

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摘要

In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method. The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties. Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity. This was attributed to the oxidase mimetic activity and the peroxidase mimicking activity of UiO-66-NH2. In such a way, the side effects of direct exposure to UV irradiation and H2O2 can be avoided for wound-healing treatments. The antibacterial mechanism was further proved by antibacterial experiments, TMB center dot 2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests. As a potential medical antibacterial dressing, in vitro membranes were also investigated.
机译：在本研究中，通过简单和环保的方法将具有过氧化物酶和氧化酶模拟活性的UIO-66-NH2金属 - 有机骨架（MOF）纳米颗粒掺入壳聚糖（CS）基质中。 UIO-66-NH2 / CS复合膜具有在H 2 O 2的痕量存在下的过氧化物酶模拟活性，因此导致良好的抗菌性能。在不存在H 2 O 2的情况下，有趣的，30分钟的UIO-66-NH2 / CS复合膜的UIO-66-NH2 / CS复合膜仍然导致良好的抗菌活性。这归因于氧化酶模拟活性和UIO-66-NH2的过氧化物酶模拟活性。以这种方式，可以避免直接暴露于UV照射和H 2 O 2的副作用以用于伤口愈合处理。通过抗菌实验，TMB中心点2HCL显色实验，反应性氧物种产生试验和电子自旋共振试验进一步证明了抗菌机制。作为潜在的医疗抗菌敷料，还研究了体外膜。

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  • 来源
    《Biomaterials Science》 |2021年第7期|共11页
  • 作者

    Wang Xiaojuan; Zhou Xuejian; Yang Kai; Li Qiong; Wan Rongxin; Hu Guoying; Ye Jin; Zhang Yue; He Jiahui; Gu Hanqing; Yang Yongfang; Zhu Lei;

  • 作者单位

    Tianjin Med Univ Hosp 2 Tianjin Peoples R China;

    Hebei Univ Technol Tianjin Peoples R China;

    Hebei Univ Technol Tianjin Peoples R China;

    Case Western Reserve Univ Macromol Sci &

    Engn Cleveland OH 44106 USA;

    Tianjin Med Univ Hosp 2 Tianjin Peoples R China;

    Tianjin Med Univ Hosp 2 Tianjin Peoples R China;

    Hebei Univ Technol Tianjin Peoples R China;

    Hebei Univ Technol Tianjin Peoples R China;

    Hebei Univ Technol Tianjin Peoples R China;

    Tianjin Med Univ Hosp 2 Tianjin Peoples R China;

    Hebei Univ Technol Tianjin Peoples R China;

    Case Western Reserve Univ Macromol Sci &

    Engn Cleveland OH 44106 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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