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Combination strategies for antithrombotic biomaterials: an emerging trend towards hemocompatibility

机译:抗血栓形成生物材料的组合策略:血液相位力的新兴趋势

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摘要

Surface-induced thrombosis is a frequent, critical issue for blood-contacting medical devices that poses a serious threat to patient safety and device functionality. Antithrombotic material design strategies including the immobilization of anticoagulants, alterations in surface chemistries and morphology, and the release of antithrombotic compounds have made great strides in the field with the ultimate goal of circumventing the need for systemic anticoagulation, but have yet to achieve the same hemocompatibility as the native endothelium. Given that the endothelium achieves this state through the use of many mechanisms of action, there is a rising trend in combining these established design strategies for improved antithrombotic actions. Here, we describe this emerging paradigm, highlighting the apparent advantages of multiple antithrombotic mechanisms of action and discussing the demonstrated potential of this new direction.
机译:表面诱导的血栓形成是血液接触医疗设备的频繁,致密的问题,对患者安全和设备功能构成严重威胁。 抗血栓形成材料设计策略,包括抗凝血剂的固定,表面化学品和形态的变化,以及抗血栓化合物的释放在该领域已经具有巨大的进展,最终目标是避免对系统性抗凝的需要,但尚未达到相同的血液相位力 作为原生内皮。 鉴于内皮通过利用许多作用机制实现了这种状态,结合这些建立的设计策略的提高抗血栓形成措施具有上升的趋势。 在这里,我们描述了这种新兴范式,突出了多种抗血栓形成机制的表观优势,并讨论了这种新方向的潜在潜力。

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  • 来源
    《Biomaterials Science》 |2021年第7期|共11页
  • 作者单位

    Univ Georgia Coll Engn Sch Chem Mat &

    Biomed Engn Athens GA 30602 USA;

    Univ Georgia Coll Engn Sch Chem Mat &

    Biomed Engn Athens GA 30602 USA;

    Univ Georgia Coll Engn Sch Chem Mat &

    Biomed Engn Athens GA 30602 USA;

    Univ Georgia Coll Engn Sch Chem Mat &

    Biomed Engn Athens GA 30602 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

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