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Gaseous microenvironmental remodeling of tumors for enhanced photo-gas therapy and real-time tracking

机译：肿瘤的气态微环境改造增强光气治疗和实时跟踪

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摘要

The gaseous microenvironment (GME) of tumors is rapidly becoming a new concern for nanotechnology-mediated oncotherapy. Here, we constructed a tumor/near-infrared (NIR) light-responsive nanoplatform to generate O-2 and NO for remodeling the GME of tumors and phototherapy. The biocompatible and pyrolytic polydopamine was used to load indocyanine green, NONOate, and MnO2 NPs as a nanoenzyme (PINM). Then, HA was modified on the PINM to form the final nanoplatform (PINMH). PINMH can target tumors favorably due to the modification of HA. Under the NIR light irradiation, PINM converts the light and O-2 to hyperpyrexia (58.5 degrees C) and cytotoxic O-1(2). MnO2 NPs catalyze the H2O2 overexpressed in tumors to O-2, which increases the amount of O-1(2). Moreover, NONOate decomposes to NO (100 mu M) under hyperpyrexia, thus leading to the gas therapy. The results verified that the responsive nanoplatform with precise gaseous regulation and phototherapy exhibited a superior anti-tumor effect (V/V-0 = 1.2) and biosafety. In addition, PINMH can be tracked in real-time via magnetic resonance imaging. In this study, an intelligent nano-platform integrated with diagnosis and treatment was developed, which used the phototherapy technology to reshape GME and achieve good anti-tumor effects, aiming to provide an innovative and reasonable strategy for the development of tumor treatment.
机译：肿瘤的气体微环境（GME）正在迅速成为纳米技术介导的干酪治疗的新关注。在这里，我们构建了一种肿瘤/近红外（NIR）光响应纳米片，以产生O-2，不用于改造肿瘤和光疗的GME。使用生物相容性和热解聚多胺用于将吲哚菁绿，非酸盐和MnO2 NPS称为纳米酶（PINM）。然后，在PINM上修饰HA以形成最终的纳米纳薄（PINMH）。由于HA的改性，Pinmh可以靶向肿瘤。在NIR光照射下，PINM将光和O-2转换为高血红蛋白（58.5℃）和细胞毒性O-1（2）。 MNO2 NPS将肿瘤中过表达的H 2 O 2催化到O-2，其增加O-1（2）的量。此外，非酸剂在高血红蛋白下分解为NO（100μm），从而导致气体治疗。结果证实，具有精确气态调节和光疗法的响应纳米片表现出优异的抗肿瘤作用（V / V-0 = 1.2）和生物安全。另外，可以通过磁共振成像实时跟踪PinmH。在这项研究中，开发了一种智能纳米平台，其集成了诊断和治疗，利用光疗技术重塑GME并实现了良好的抗肿瘤效果，旨在为肿瘤治疗的发展提供创新和合理的策略。

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  • 来源
    《Biomaterials Science》 |2021年第6期|共9页
  • 作者

    He Yuchu; Cong Cong; Zhao Shuxian; Li Zhuo; Wang Desong; Gu Jianmin; Liu Lanxiang; Gao Dawei;

  • 作者单位

    Yanshan Univ Hebei Key Lab Heavy Met Deep Remediat Water &

    Res Applying Chem Key Lab Hebei Prov State Key Lab Metastable Mat Sci &

    Technol Qinhuangdao 066004 Hebei Peoples R China;

    Yanshan Univ Hebei Key Lab Heavy Met Deep Remediat Water &

    Res Applying Chem Key Lab Hebei Prov State Key Lab Metastable Mat Sci &

    Technol Qinhuangdao 066004 Hebei Peoples R China;

    Yanshan Univ Hebei Key Lab Heavy Met Deep Remediat Water &

    Res Applying Chem Key Lab Hebei Prov State Key Lab Metastable Mat Sci &

    Technol Qinhuangdao 066004 Hebei Peoples R China;

    Yanshan Univ Hebei Key Lab Heavy Met Deep Remediat Water &

    Res Applying Chem Key Lab Hebei Prov State Key Lab Metastable Mat Sci &

    Technol Qinhuangdao 066004 Hebei Peoples R China;

    Yanshan Univ Hebei Key Lab Heavy Met Deep Remediat Water &

    Res Applying Chem Key Lab Hebei Prov State Key Lab Metastable Mat Sci &

    Technol Qinhuangdao 066004 Hebei Peoples R China;

    Yanshan Univ Hebei Key Lab Heavy Met Deep Remediat Water &

    Res Applying Chem Key Lab Hebei Prov State Key Lab Metastable Mat Sci &

    Technol Qinhuangdao 066004 Hebei Peoples R China;

    Qinhuangdao Municipal 1 Hosp Dept Magnet Resonance Imaging Qinhuangdao Hebei Peoples R China;

    Yanshan Univ Hebei Key Lab Heavy Met Deep Remediat Water &

    Res Applying Chem Key Lab Hebei Prov State Key Lab Metastable Mat Sci &

    Technol Qinhuangdao 066004 Hebei Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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