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首页> 外文期刊>Biomaterials Science >Electrospun artificial periosteum loaded with DFO contributes to osteogenesis via the TGF-beta 1/Smad2 pathway
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Electrospun artificial periosteum loaded with DFO contributes to osteogenesis via the TGF-beta 1/Smad2 pathway

机译：载有DFO的Electurpum人造骨膜通过TGF-Beta 1 / Smad2途径有助于骨质发生

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摘要

Deferoxamine (DFO), an iron chelator regarded as a hypoxic analogue, has been reported to be involved in angiogenesis and osteogenic differentiation. In this study, DFO was loaded into nanospheres, Then, DFO-loaded NPs and free DFO were co-encapsulated in nanofibers through coaxial electrospinning and its effects on cell viability, migration, and osteogenic differentiation, and the potential mechanisms were investigated. The results suggested that DFO maintained cell viability and promoted the migration of human mesenchymal stem cells (hMSCs) and MC3T3-E1 cells. ALP activity, calcium deposition, and expression of osteogenesis-related markers, including collagen, osteocalcin, and osteopontin, were all increased with DFO. Moreover, hypoxia-inducible factor-1 alpha, transforming growth factor-beta, and Smad2 were upregulated with DFO, which indicated activation of the TGF-beta 1/Smad2 signalling pathway. This may contribute to osteogenic differentiation of cells.
机译：据报道，Deferoxamine（DFO），被认为是一种缺氧类似物的铁螯合剂，参与血管生成和成骨分化。 在该研究中，DFO被装载到纳米球中，然后通过同轴电刺激术和其对细胞活力，迁移和骨质发生分化的影响，将DFO负载的NPS和游离DFO共封装在纳米纤维中，并研究了潜在机制。 结果表明，DFO保持细胞活力并促进人间充质干细胞（HMSCs）和MC3T3-E1细胞的迁移。 ALP活性，钙沉积和骨质发生相关标记的表达，包括胶原蛋白，骨钙素和骨桥蛋白，都随着DFO而增加。 此外，用DFO上调缺氧诱导因子-1α，转化生长因子-β和Smad2，表明TGF-β1/ Smad2信号通路的激活。 这可能有助于对细胞的骨质发生分化。

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  • 来源
    《Biomaterials Science》 |2021年第6期|共13页
  • 作者

    Shi Rui; Zhang Jingshuang; Niu Kun; Li Weiyang; Jiang Ni; Li Jianlin; Yu Qingsong; Wu Chengai;

  • 作者单位

    Beijing Jishuitan Hosp Beijing Inst Traumatol &

    Orthpaed Beijing 100035 Peoples R China;

    Beijing Jishuitan Hosp Beijing Inst Traumatol &

    Orthpaed Beijing 100035 Peoples R China;

    Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China;

    Beijing Jishuitan Hosp Beijing Inst Traumatol &

    Orthpaed Beijing 100035 Peoples R China;

    Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China;

    Beijing Jishuitan Hosp Beijing Inst Traumatol &

    Orthpaed Beijing 100035 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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