• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomaterials Science >Liquid exfoliated biocompatible WS2@BSA nanosheets with enhanced theranostic capacity
【24h】

Liquid exfoliated biocompatible WS2@BSA nanosheets with enhanced theranostic capacity

机译：液体去角化生物相容性WS2 @ BSA纳米蛋白酶，其具有增强的治疗能力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ultrathin transition metal dichalcogenides (TMDs) seem to have a promising future in the field of theranostic agents due to their excellent near-infrared light absorption capacity and large specific surface area. Plenty of previous studies focused on the therapeutic effects of the materials, but were less concerned with the detailed studies of biocompatibility for clinical transformation. In this work, ultrathin WS2 nanosheets coated with bovine serum protein (BSA) (WS2@BSA NSs) were selected as experimental subjects with favorable biocompatibility to explore their potential as a theranostic agent. Firstly, ultrathin WS2 nanosheets were prepared by ultrasound-assisted exfoliation using n-methyl pyrrolidone (NMP) as the liquid phase, followed by coating with bovine serum protein. The physical and chemical properties of WS2@BSA NSs were investigated. Secondly, the biocompatibility experiments that are most relevant to clinical transformation were divided into cell level experiments and in vivo experiments with zebrafish as the model organism. Finally, to explore further applications for the diagnosis and treatment of tumors, the in vitro photothermal effect and the X-ray computed tomography (CT) imaging capability of WS2@BSA NSs were investigated. The obtained results were promising in terms of biocompatibility and theranostics, which suggested the potential of WS2@BSA NSs for use as a multifunctional theranostic agent in clinics.
机译：超薄过渡金属二甲基甲基（TMDS）似乎在其在治疗剂领域具有未来的未来，由于它们出色的近红外光吸收能力和大的比表面积。以前的大量研究侧重于材料的治疗效果，但较少涉及对临床转化的生物相容性的详细研究。在这项工作中，选择涂有牛血清蛋白（BSA）（BSA）（WS2 @ BSA NSS）的超薄WS2纳米片作为实验对象，具有良好的生物相容性，以探讨其作为治疗剂的潜力。首先，通过使用N-甲基吡咯烷酮（NMP）作为液相来制备超声波WS2纳米片，然后用牛血清蛋白涂覆。研究了WS2 @ BSA NSS的物理和化学性质。其次，与临床转化最相关的生物相容性实验分为细胞水平实验，并在斑马鱼作为模型生物的体内实验。最后，为了探讨肿瘤的诊断和治疗的进一步应用，研究了WS2 @ BSA NSS的体外光热效应和X射线计算断层扫描（CT）成像能力。所获得的结果在生物相容性和治疗方法方面具有很有希望，这表明WS2 @ BSA NSS的潜力是诊所中的多官能治疗剂。

著录项

  • 来源
    《Biomaterials Science》 |2021年第1期|共9页
  • 作者

    Yi Haoyang; Zhou Xinyue; Zhou Chaohui; Yang Qingye; Jia Nengqin;

  • 作者单位

    Shanghai Normal Univ Coll Chem &

    Mat Sci Key Lab Resource Chem Shanghai Key Lab Rare Earth Funct Mat Educ Minist Shanghai 200234 Peoples R China;

    Shanghai Normal Univ Coll Chem &

    Mat Sci Key Lab Resource Chem Shanghai Key Lab Rare Earth Funct Mat Educ Minist Shanghai 200234 Peoples R China;

    Shanghai Normal Univ Coll Chem &

    Mat Sci Key Lab Resource Chem Shanghai Key Lab Rare Earth Funct Mat Educ Minist Shanghai 200234 Peoples R China;

    Shanghai Normal Univ Coll Chem &

    Mat Sci Key Lab Resource Chem Shanghai Key Lab Rare Earth Funct Mat Educ Minist Shanghai 200234 Peoples R China;

    Shanghai Normal Univ Coll Chem &

    Mat Sci Key Lab Resource Chem Shanghai Key Lab Rare Earth Funct Mat Educ Minist Shanghai 200234 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号