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SERS diagnosis of liver fibrosis in the early stage based on gold nanostar liver targeting tags

机译：基于金纳盘肝脏靶向标签的早期肝纤维化的SERS诊断

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摘要

In order to realize the accurate and early diagnosis of liver fibrosis, a long slow pathological process which may lead to cirrhosis or even liver cancer, liver targeting tags made up of gold nanostars and glycyrrhetinic acid are reported in this paper. Gold nanostars (GNSs) and GNS liver targeting tags (GLTTs) were injected into model mice with stage S-1 liver fibrosis and normal mice via the tail vein respectively, then the SERS spectra were collected. GLTTs had a better detection effect on liver tissue than unmodified GNSs (12.85 times), and better detection reproducibility as well. Moreover, according to the MTT and survival analysis experiments, GLTTs also had better biocompatibility. Hence, the changes of 10 SERS signals and other substances in the early stage of liver fibrosis were analyzed at the molecular level, and the SERS characteristic peaks that could be used for the diagnosis of early liver fibrosis were screened out. Revealed by the experimental results, the GLTTs designed and prepared were applicable to the efficient SERS detection of early liver fibrosis in mice, and the strategy we have proposed might be a potential approach for the early diagnosis of this disease in clinics.
机译：为了实现肝纤维化的准确性和早期诊断，在本文中报道了一种可能导致肝硬化或甚至肝癌的肝硬化甚至肝癌的肝脏靶向标签。将金纳米杆菌（GNSS）和GNS肝脏靶向标签（GNS肝脏靶向标签（GNS）分别通过尾静脉注射到模型小鼠中，分别通过尾静脉进行正常小鼠，然后收集SERS光谱。 GLTTS对肝脏组织的检测效果比未修饰的GNSS（12.85次），以及更好的检测再现性。此外，根据MTT和生存分析实验，GLTTS也具有更好的生物相容性。因此，在分子水平上分析了肝纤维化早期阶段的10个SERS信号和其他物质的变化，筛选出可用于诊断早期肝纤维化的SERS特征峰。通过实验结果揭示，设计和制备的GLTTS适用于小鼠早期肝纤维化的有效SERS检测，我们提出的策略可能是诊所早期诊断本病的潜在方法。

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  • 来源
    《Biomaterials Science》 |2021年第14期|共10页
  • 作者

    Xiang Songtao; Lu Lin; Zhong Huiqing; Lu Min; Mao Hua;

  • 作者单位

    Southern Med Univ Zhujiang Hosp Dept Digest Med Guangzhou 510282 Peoples R China;

    Southern Med Univ Zhujiang Hosp Dept Digest Med Guangzhou 510282 Peoples R China;

    South China Normal Univ State Inst Biophoton State Adm Tradit Chinese Med Guangzhou 510631 Peoples R China;

    Southern Med Univ Zhujiang Hosp Dept Digest Med Guangzhou 510282 Peoples R China;

    Southern Med Univ Zhujiang Hosp Dept Digest Med Guangzhou 510282 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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