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首页> 外文期刊>Biomaterials Science >The synergistic effect of hierarchical structure and alkyl chain length on the antifouling and bactericidal properties of cationic/zwitterionic block polymer brushes
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The synergistic effect of hierarchical structure and alkyl chain length on the antifouling and bactericidal properties of cationic/zwitterionic block polymer brushes

机译：层次结构和烷基链长度对阳离子/两性离子嵌段聚合物刷的防污性和杀菌性能的协同作用

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摘要

Creating hierarchical polymer brushes possessing antifouling and bactericidal functionalities is a promising approach to combat biomaterial-associated infections. Hence, a well-constructed hierarchical structure is required to achieve optimized antibacterial performance. In this work, contact-killing cationic bactericidal poly(quaternary ammonium salts) (PQAs) bearing different alkyl chain lengths and zwitterionic antifouling poly(sulfobetaine methacrylate) (PSBMA) functional segments were grafted onto an activated substrate via surface-initiated atom transfer radical polymerization (SI-ATRP), and three kinds of polymer brushes with different architectures (Si-PQAs-b-PSBMA, Si-PSBMA-b-PQAs and Si-PQAs-r-PSBMA) were constructed. We demonstrate that the antibacterial effect simultaneously depends on the alkyl chain lengths of PQAs and the hierarchical structure of cationic/zwitterionic segments in polymer brushes. When the polymer brushes composed of a bactericidal bottom layer and an antifouling top layer, the ideal alkyl chain length of PQAs should be eight carbon atoms (Si-PQA8C-b-PSBMA), while in the opposite hierarchical structure, the optimized alkyl chain length of PQAs to synergize with PSBMA was four carbon atoms (Si-PSBMA-b-PQA4C). By appropriately adjusting the alkyl chain length or the hierarchical architecture, the interference between the antifouling and bactericidal functions could be avoided, thus achieving the outstanding long-term antibacterial performance against S. aureus, as well as good hemocompatibility and low cytotoxicity. This work provides fundamental guidance for the design and optimization of efficient and reliable antibacterial surfaces to inhibit biofilm formation.
机译：形成具有防污和杀菌功能的分层聚合物刷是对抗生物材料相关感染的有希望的方法。因此，需要良好构造的层级结构来实现优化的抗菌性能。在这项工作中，通过表面引发的原子转移自由基聚合将携带不同烷基链长度和两性离子防污聚（Sulfobetaine甲基丙烯酸酯）（PSBMA）官能段（PSBMA）官能分段的接触杀灭阳离子杀菌聚（氨基盐）（PQAS） （Si-ATRP）和三种具有不同架构的聚合物刷（Si-PQAs-B-PSBMA，Si-PSBMA-B-PQAs和Si-PQAS-R-PSBMA）。我们证明抗菌作用同时取决于PQA的烷基链长度和聚合物刷中阳离子/两性离子区段的分层结构。当由杀菌底层和防污顶层组成的聚合物刷子时，PQAs的理想烷基链长度应为八个碳原子（Si-PQA8C-B-PSBMA），而在相对的层级结构中，优化的烷基链长度用PSBMA进行协同的PQA是四个碳原子（Si-PSBMA-B-PQA4C）。通过适当地调节烷基链长度或分层架构，可以避免防污和杀菌功能之间的干扰，从而实现针对金黄色葡萄球菌的突出的长期抗菌性能，以及良好的血液相位力和低细胞毒性。这项工作为高效且可靠的抗菌表面的设计和优化提供了基本指导，以抑制生物膜形成。

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  • 来源
    《Biomaterials Science》 |2020年第24期|共13页
  • 作者

    Yuanyuan He; Xinyuan Wan; Weiwei Lin; Jiehua Li; Zhen Li; Feng Luo; Jianshu Li; Hong Tan; Qiang Fu;

  • 作者单位

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

    College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China;

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  • 中图分类 计量学;
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